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基于生物信息学分析的黄曲霉毒素诱导肝细胞癌的分子机制。

Molecular Mechanism of Aflatoxin-Induced Hepatocellular Carcinoma Derived from a Bioinformatics Analysis.

机构信息

College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.

Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.

出版信息

Toxins (Basel). 2020 Mar 23;12(3):203. doi: 10.3390/toxins12030203.

DOI:10.3390/toxins12030203
PMID:32210020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7150856/
Abstract

Exposure to aflatoxin is considered to be one of the causes of hepatocellular carcinoma (HCC). With the development of bioinformation, we sought to reveal the occurrence and development of aflatoxin-induced HCC through data research. We identified differentially expressed genes (DEGs) of datasets GSE127791 (Aflatoxin-treated pluripotent stem cell derived human hepatocytes vs. controls) and GSE64041 (liver carcinoma with unknown cause vs. non-cancerous tissue) by GEO2R to find the common DEGs. Gene ontology (GO) and KEGG path enrichment analysis were used to annotate the function of DEGs. Hub genes were screened from identified DEGs by protein-protein interaction (PPI) network analysis. The prognostic value of hub genes in cancer databases were evaluated. We obtained 132 common DEGs and 11 hub genes. According to cluster analysis and protein co-expression networks, we screened out the key genes, histidine-rich glycoprotein (HRG) and phosphoenolpyruvate carboxykinase 2 (PCK2). Oncomine database and survival curve analysis showed that the decline in HRG and PCK2 expression in the development of HCC indicated poor prognosis. We speculated that the decreased expression of HRG and PCK2 after aflatoxin exposure to hepatocyte may be related to aflatoxin induced hepatocyte injury and carcinogenesis. In addition, the decreased expression of HRG and PCK2 in the occurrence and development of HCC suggests a poor prognosis of HCC.

摘要

黄曲霉毒素暴露被认为是肝细胞癌 (HCC) 的病因之一。随着生物信息学的发展，我们试图通过数据研究揭示黄曲霉毒素诱导 HCC 的发生和发展。我们通过 GEO2R 从 GSE127791 数据集（黄曲霉处理的多能干细胞衍生的人肝细胞与对照）和 GSE64041 数据集（未知原因的肝癌与非癌组织）中鉴定差异表达基因 (DEGs)，以找到共同的 DEGs。基因本体论 (GO) 和 KEGG 通路富集分析用于注释 DEGs 的功能。通过蛋白质-蛋白质相互作用 (PPI) 网络分析从鉴定的 DEGs 中筛选出枢纽基因。评估了癌症数据库中枢纽基因的预后价值。我们获得了 132 个共同的 DEGs 和 11 个枢纽基因。根据聚类分析和蛋白质共表达网络，我们筛选出关键基因，组氨酸丰富糖蛋白 (HRG) 和磷酸烯醇丙酮酸羧激酶 2 (PCK2)。Oncomine 数据库和生存曲线分析表明，HRG 和 PCK2 表达在 HCC 发展中的下降表明预后不良。我们推测，黄曲霉毒素暴露后肝细胞中 HRG 和 PCK2 的表达下降可能与黄曲霉毒素诱导的肝细胞损伤和致癌作用有关。此外，HRG 和 PCK2 在 HCC 发生和发展中的表达降低提示 HCC 预后不良。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/b07f569f6773/toxins-12-00203-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/962838a1c157/toxins-12-00203-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/db842ee219d6/toxins-12-00203-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/521067aa9118/toxins-12-00203-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/532712cf4f81/toxins-12-00203-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/b07f569f6773/toxins-12-00203-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/962838a1c157/toxins-12-00203-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/a6716948dafb/toxins-12-00203-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/db842ee219d6/toxins-12-00203-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/521067aa9118/toxins-12-00203-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/ecb74f286e6a/toxins-12-00203-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/532712cf4f81/toxins-12-00203-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e612/7150856/b07f569f6773/toxins-12-00203-g007.jpg

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Arch Toxicol. 2019 Nov;93(11):3335-3344. doi: 10.1007/s00204-019-02569-5. Epub 2019 Sep 25.
3
A global view of hepatocellular carcinoma: trends, risk, prevention and management.
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5
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6
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