Liu Yuliang, Zhang Quan, Zhao Geng, Liu Guohua, Liu Zhiang
College of Electronic Information and Automation, Tianjin University of Science and Technology, Tianjin 300222, People's Republic of China.
Tianjin Medical University Hospital for Metabolic Disease, Tianjin 300134, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 Mar 11;13:679-691. doi: 10.2147/DMSO.S242585. eCollection 2020.
The research of auxiliary diagnosis has always been one of the hotspots in the world. The implementation of auxiliary diagnosis support algorithm for medical text data faces challenges with interpretability and creditability. The improvement of clinical diagnostic techniques means not only the improvement of diagnostic accuracy but also the further study of diagnostic basis. Traditional research methods for diagnostic markers often require a large amount of time and economic costs. Research objects are often dozens of samples, and it is, therefore, difficult to synthesize large amounts of data. Therefore, the comprehensiveness and reliability of traditional methods have yet to be improved. Therefore, the establishment of a model that can automatically diagnose diseases and automatically provide a diagnostic basis at the same time has a positive effect on the improvement of medical diagnostic techniques.
Here, we established an auxiliary diagnostic tool based on attention deep learning algorithm to diagnostic hyperlipemia and automatically predict the corresponding diagnostic markers using hematological parameters. In this paper, we not only demonstrated the ability of the proposed model to automatically diagnose diseases using text-based medical data, such as physiological parameters, but also demonstrated its ability to forecast disease diagnostic markers. Human physiological parameters are used as input to the model, and the doctor's diagnosis results as an output. Through the attention layer, the degree of attention of the model to different physiological parameters can be obtained, that is, the model provides a diagnostic basis.
It achieved 94% ACC, 97.48% AUC, 96% sensitivity and 92% specificity with the test dataset. All the above samples are drawn from clinical practice. Moreover, the model predicted the diagnostic markers of hyperlipidemia by the attention mechanism, and the results were fully agreeable to the golden criteria.
The auxiliary diagnosis system proposed in this paper not only achieves the accurate and robust performance, and can be used for the preliminary diagnosis of patients, but also showing its great potential to discover new diagnostic markers. Therefore, it not only can improve the efficiency of clinical diagnosis but also shorten the research period of researching a diagnosis basis to an extent. It has a positive significance to the development of the medical diagnosis level.
辅助诊断研究一直是全球热点之一。医学文本数据辅助诊断支持算法的实施面临着可解释性和可信度方面的挑战。临床诊断技术的提高不仅意味着诊断准确性的提高,还意味着对诊断依据的进一步研究。传统的诊断标志物研究方法往往需要大量的时间和经济成本。研究对象通常只有几十个样本,因此难以综合大量数据。因此,传统方法的全面性和可靠性还有待提高。因此,建立一个能够同时自动诊断疾病并自动提供诊断依据的模型,对医学诊断技术的提高具有积极作用。
在此,我们基于注意力深度学习算法建立了一种辅助诊断工具,用于诊断高脂血症,并利用血液学参数自动预测相应的诊断标志物。在本文中,我们不仅展示了所提出模型使用基于文本的医学数据(如生理参数)自动诊断疾病的能力,还展示了其预测疾病诊断标志物的能力。人体生理参数用作模型的输入,医生的诊断结果作为输出。通过注意力层,可以获得模型对不同生理参数的关注程度,即模型提供了诊断依据。
在测试数据集上,其准确率达到94%,曲线下面积(AUC)为97.48%,灵敏度为96%,特异性为92%。以上所有样本均取自临床实践。此外,该模型通过注意力机制预测了高脂血症的诊断标志物,结果与金标准完全一致。
本文提出的辅助诊断系统不仅实现了准确且稳健的性能,可用于患者的初步诊断,还显示出其在发现新诊断标志物方面的巨大潜力。因此,它不仅可以提高临床诊断效率,还能在一定程度上缩短诊断依据的研究周期。对医学诊断水平的发展具有积极意义。