Kanmura Shuji, Tanaka Akihito, Yutsudou Kazuki, Kuwazuru Kosuke, Komaki Fukiko, Komaki Yuga, Iwaya Hiromichi, Arima Shiho, Sasaki Fumisato, Tanoue Shiroh, Hashimoto Shinichi, Ido Akio
Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Gastroenterol Res Pract. 2020 Mar 6;2020:3108690. doi: 10.1155/2020/3108690. eCollection 2020.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology. Recently, mucosal healing has emerged as an important therapeutic endpoint in UC. Linked color imaging (LCI) is a novel endoscopic system that enhances the color differences of the gastrointestinal mucosa. Our previous study emphasized the redness and yellowness of the lesion using LCI observation, which was useful for the evaluation of histological mucosal activity in UC. In this study, we aimed to evaluate the correlation between LCI observation and clinical relapse rate in UC patients. We retrospectively analyzed UC patients who underwent total colonoscopy between August 2016 and October 2018 at our facility with Mayo endoscopic scores of 0 or 1. We assessed the correlation between orange-like color lesion (defined as LCI-scarlet color lesions) and clinical relapse rate (requiring additional treatment for UC) during the 1-year follow-up period. Fifty-eight patients (22 female, 36 male; median age at diagnosis, 47.2 (18-80) years) who underwent colonoscopy were analyzed. During the 1-year follow-up period, clinical relapse was observed in 12 patients (20.1%) among which ten patients (83.3%) had an LCI-scarlet color lesions recognized by LCI. By contrast, 29 patients (63%) had no LCI-scarlet color lesions in the clinical remission group ( = 46). There was a significant difference in LCI-scarlet color between the clinical relapse and remission groups, remaining significantly associated with clinical relapse. LCI findings, including an orange-like color lesion, have diagnostic implications for predicting the risk of clinical relapse in UC during the 1-year follow-up period.
溃疡性结肠炎（UC）是一种病因不明的慢性炎症性肠病。近年来，黏膜愈合已成为UC重要的治疗终点。联动成像（LCI）是一种新型内镜系统，可增强胃肠道黏膜的颜色差异。我们之前的研究强调了使用LCI观察病变的红色和黄色，这对评估UC的组织学黏膜活性很有用。在本研究中，我们旨在评估LCI观察结果与UC患者临床复发率之间的相关性。我们回顾性分析了2016年8月至2018年10月在我们机构接受全结肠镜检查、Mayo内镜评分为0或1的UC患者。我们评估了类橙色病变（定义为LCI-猩红色病变）与1年随访期内临床复发率（需要对UC进行额外治疗）之间的相关性。分析了58例接受结肠镜检查的患者（22例女性，36例男性；诊断时的中位年龄为47.2（18-80）岁）。在1年随访期内，12例患者（20.1%）出现临床复发，其中10例患者（83.3%）经LCI检查发现有LCI-猩红色病变。相比之下，临床缓解组（n = 46）中有29例患者（63%）没有LCI-猩红色病变。临床复发组和缓解组之间LCI-猩红色病变存在显著差异，且与临床复发仍显著相关。包括类橙色病变在内的LCI检查结果对预测UC患者1年随访期内临床复发风险具有诊断意义。
