Howard W F, Chihal H J, Strain C A, Smith M
Texas Endocrine and Fertility Institute, Carrollton 75010.
J In Vitro Fert Embryo Transf. 1988 Dec;5(6):343-6. doi: 10.1007/BF01129570.
To reduce cycle cost and patient/staff stress in an ongoing in vitro fertilization (IVF) program, we have utilized a modified "programmed" (PP) follicle stimulation protocol with limited monitoring. We have compared our PP results with those using a conventional, individualized, and fully monitored protocol (OP) in order to show that PP does not compromise the quality of care. Hormonal presuppression made possible an arbitrary starting day for the cycle. In 80% of the cycles, oocyte retrieval (OR) was performed on the planned day or 1 day later. There was no statistically significant difference between the two regimens in oocyte/embryo numbers, quality or pregnancy rates. The cycle cost was significantly reduced. In addition, patient stress was lessened because of the reasonable predictability of cycle timing. We conclude that PP has significant financial and emotional advantages for the patient over OP but does not appear to diminish the chance for pregnancy in an IVF cycle. PP also allows program staff to manage time more effectively, thereby reducing staff stress.
为降低正在进行的体外受精（IVF）项目中的周期成本以及患者/工作人员的压力，我们采用了一种经过改良的“程序化”（PP）卵泡刺激方案，并减少了监测。我们将PP方案的结果与使用传统的、个体化的且进行全面监测的方案（OP）的结果进行了比较，以表明PP方案不会影响护理质量。激素预抑制使得周期可以在任意一天开始。在80%的周期中，卵母细胞采集（OR）在计划日期或之后一天进行。两种方案在卵母细胞/胚胎数量、质量或妊娠率方面没有统计学上的显著差异。周期成本显著降低。此外，由于周期时间具有合理的可预测性，患者的压力减轻了。我们得出结论，与OP方案相比，PP方案对患者具有显著的经济和情感优势，但似乎不会降低IVF周期中的妊娠几率。PP方案还使项目工作人员能够更有效地管理时间，从而减轻工作人员的压力。
