Cao Yanna, Drake Madeline, Davis Joy, Yang Baibing, Ko Tien C
Department of Surgery, The University of Texas Health Science Center, USA.
Adv Res Gastroenterol Hepatol. 2019;13(5). Epub 2019 Sep 4.
Bone morphogenetic proteins (BMPs) comprise a major subgroup of the transforming growth factor (TGF)-β superfamily. They play pivotal roles in embryonic development and tissue homeostasis in adults. Deregulation of BMP and TGF-β signaling contributes to developmental anomalies and multiple diseases. In this mini-review, we focus on BMP signaling in inflammatory disorders of the pancreas, acute and chronic pancreatitis, in contrast to TGF-β signaling. We then discuss molecular mechanisms that interact with and connect between the BMP and TGF-β signaling pathways. Lastly, we review potential implications of these molecular mechanisms for therapeutic development. In summary, BMP signaling pathway plays different roles during pancreatitis disease development, and the antagonism between BMP and TGF-β signaling can be manipulated for therapeutic development against pancreatitis.
骨形态发生蛋白（BMPs）是转化生长因子（TGF）-β超家族的一个主要亚组。它们在胚胎发育和成人组织稳态中发挥关键作用。BMP和TGF-β信号失调会导致发育异常和多种疾病。在本综述中，与TGF-β信号相反，我们重点关注BMP信号在胰腺炎症性疾病、急性和慢性胰腺炎中的作用。然后，我们讨论了与BMP和TGF-β信号通路相互作用并相互连接的分子机制。最后，我们综述了这些分子机制在治疗开发中的潜在意义。总之，BMP信号通路在胰腺炎疾病发展过程中发挥不同作用，并且可以通过操纵BMP和TGF-β信号之间的拮抗作用来开发针对胰腺炎的治疗方法。
