Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, China; Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Pharmacol Res. 2019 Apr;142:58-69. doi: 10.1016/j.phrs.2019.01.038. Epub 2019 Jan 22.
Pancreatic diseases, such as acute pancreatitis, chronic pancreatitis, and pancreatic cancer, are common gastrointestinal diseases resulting in the development of local and systemic complications with a high risk of death. Numerous studies have examined pancreatic diseases over the past few decades; however, the pathogenesis remains unclear, and there is a lack of effective treatment options. Recently, emerging evidence has suggested that transforming growth factor beta (TGF-β) exerts controversial functions in apoptosis, inflammatory responses, and carcinogenesis, indicating its complex role in the pathogenesis of pancreas-associated disease. Therefore, a further understanding of relevant TGF-β signalling will provide new ideas and potential therapeutic targets for preventing disease progression. This is the first systematic review of recent data from animal and human clinical studies focusing on TGF-β signalling in pancreas damage and diseases. This information may aid in the development of therapeutic agents for regulating TGF-β in this pathology to prevent or treat pancreatic diseases.
胰腺疾病,如急性胰腺炎、慢性胰腺炎和胰腺癌,是常见的胃肠道疾病,会导致局部和全身并发症的发生,死亡率较高。在过去几十年中,许多研究都对胰腺疾病进行了研究;然而,其发病机制仍不清楚,并且缺乏有效的治疗方法。最近,新出现的证据表明转化生长因子β(TGF-β)在细胞凋亡、炎症反应和致癌作用中发挥着有争议的作用,表明其在与胰腺相关的疾病发病机制中具有复杂的作用。因此,进一步了解相关的 TGF-β 信号转导将为预防疾病进展提供新的思路和潜在的治疗靶点。这是第一篇对动物和人类临床研究中有关 TGF-β 信号转导在胰腺损伤和疾病中的最新数据的系统综述。这些信息可能有助于开发调节 TGF-β 的治疗剂,以预防或治疗胰腺疾病。