Department of Chemistry and Materials Science, College of Science, Nanjing Forestry University, Nanjing 210037, China.
Chem Commun (Camb). 2020 Apr 30;56(34):4676-4679. doi: 10.1039/d0cc00988a. Epub 2020 Mar 25.
A novel transformation for the construction of Csp-Csp bonds was achieved via a photo-induced copper-catalysed C-C bond cleavage. This approach was applied to prepare a series of highly functionalized alkynyl nitriles using readily available cyclobutanones and terminal alkynes. Mechanistic exploration showed that the in situ generated copper acetylide complex is an effective photosensitive catalyst to promote the C-C bond cleavage of cycloketoxime esters through a radical process.
通过光诱导的铜催化 C-C 键断裂，实现了 Csp-Csp 键构建的新转化。该方法用于使用易得的环丁酮和末端炔烃制备一系列高官能化的炔基腈。机理研究表明，原位生成的铜炔化物配合物是一种有效的光敏催化剂，通过自由基过程促进环酮肟酯的 C-C 键断裂。
