Department of Chemistry, School of Science and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiaotong University , Xi'an 710049, China.
J Org Chem. 2018 Jan 19;83(2):1046-1055. doi: 10.1021/acs.joc.7b02714. Epub 2017 Dec 29.
The copper-catalyzed cyclization of activated alkenes with cyclobutanone O-acyl oximes under redox-neutral conditions has been reported. This facile protocol provided an efficient approach to a variety of cyanoalkylated oxindoles and dihydroquinolin-2(1H)-ones with a broad substrate scope and excellent functional group tolerance. In this reaction, sequential C-C bond cleavage, radical addition, and cyclization processes were involved, wherein multiple bonds were constructed in a one-pot reaction. Mechanistic studies suggest that the reaction probably proceeded via a radical pathway.
报道了在氧化还原中性条件下，铜催化的活性烯烃与环丁酮 O-酰基肟的环化反应。该简便的方案为各种氰基烷基化的吲哚啉酮和二氢喹啉-2(1H)-酮提供了一种有效的方法，具有广泛的底物范围和优异的官能团耐受性。在这个反应中，涉及到顺序的 C-C 键断裂、自由基加成和环化过程，其中在一锅反应中构建了多个键。机理研究表明，反应可能是通过自由基途径进行的。
