Department of Neurology, Wroclaw Medical University, Wroclaw, Poland.
Faculty of Earth Sciences and Environmental Management, University of Wroclaw, Wroclaw, Poland.
Neurol Sci. 2020 Sep;41(9):2495-2501. doi: 10.1007/s10072-020-04351-3. Epub 2020 Mar 24.
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease of the peripheral nervous system, sometimes including the central nervous system. The aim of the study was the assessment of the prevalence of central sensory impairment and its reliance on peripheral nerve damage in patients with CIDP.
Multimodal (visual-VEP, brainstem auditory-BAEP, somatosensory-SEP) evoked potentials (EPs) were studied in 24 patients diagnosed with CIDP. The results were compared with neurographic parameters of sensory responses. The control group consisted of 35 healthy volunteers selected with respect to age and sex.
Mean latency of most components of EP were considerably prolonged in patients compared with the control group. There were no correlations between the P100 VEP latency and the peripheral sensory parameters. Statistically significant negative correlations were obtained between BAEP and SEP responses and the amplitude and sensory conduction velocity of peripheral nerves. The inter-latencies were also longer.
The authors indicated to the possibility of central sensory involvement in patients with CIDP, especially based on the prolonged inter-latency of BAEPs with simultaneously confirmed root affection. The severity of central damage correlates with the degree of peripheral nerve impairment.
慢性炎症性脱髓鞘性多发性神经病（CIDP）是一种自身免疫性疾病，影响外周神经系统，有时也包括中枢神经系统。本研究旨在评估 CIDP 患者中枢感觉障碍的发生率及其对周围神经损伤的依赖关系。
对 24 例确诊为 CIDP 的患者进行多模态（视觉 VEP、脑干听觉 BAEP、体感 SEP）诱发电位（EP）研究。将结果与感觉反应的神经图参数进行比较。对照组由 35 名年龄和性别匹配的健康志愿者组成。
与对照组相比，患者的 EP 大多数成分的潜伏期明显延长。P100 VEP 潜伏期与周围感觉参数之间无相关性。BAEP 和 SEP 反应与周围神经的振幅和感觉传导速度之间存在显著的负相关。潜伏期也更长。
作者指出 CIDP 患者可能存在中枢感觉受累，特别是基于 BAEPs 的潜伏期延长，同时证实神经根受累。中枢损伤的严重程度与周围神经损伤的程度相关。
