Ashley Anthony L, Delaski Kristina M, Watson Allison M
Chattanooga Zoo, Chattanooga, TN 37404, USA,
Department of Conservation Medicine, Smithsonian Conservation Biology Institute, National Zoological Park, Front Royal, VA 22630, USA.
J Zoo Wildl Med. 2020 Mar 17;51(1):188-195. doi: 10.1638/2019-0026.
Two geriatric red pandas () over a 4-yr period presented with vague clinical signs including anorexia, lethargy, and difficulty ambulating. Treatment protocols using enrofloxacin, steroids, and clindamycin were unsuccessful. Necropsy examination confirmed disseminated toxoplasmosis infection in these cases, and a modified agglutination test had been positive for a prolonged period of time before one panda showed signs of disease. A review of the Red Panda Species Survival Plan pathology database revealed two additional cases of disseminated toxoplasmosis in geriatric red pandas. Many organ systems were affected, but dissemination to the brain, lungs, and liver predominated. Immunohistochemistry or polymerase chain reaction was required to confirm a diagnosis in serologically positive animals, as well as in animals in which a histological diagnosis was suspected. This case series describes the clinical and pathological features of toxoplasmosis in geriatric red pandas.
在4年时间里，两只老年小熊猫出现了包括厌食、嗜睡和行走困难等模糊的临床症状。使用恩诺沙星、类固醇和克林霉素的治疗方案均未成功。尸检证实这些病例存在播散性弓形虫感染，并且在一只小熊猫出现疾病迹象之前，改良凝集试验长时间呈阳性。对小熊猫物种生存计划病理数据库的回顾发现了另外两例老年小熊猫播散性弓形虫病病例。许多器官系统都受到影响，但以扩散到脑、肺和肝脏为主。对于血清学阳性的动物以及疑似有组织学诊断的动物，需要进行免疫组织化学或聚合酶链反应来确诊。本病例系列描述了老年小熊猫弓形虫病的临床和病理特征。
