Epstein F, Wisoff J H
Division of Pediatric Neurosurgery, New York University Medical Center, NY 10016.
J Neurooncol. 1988 Dec;6(4):309-17. doi: 10.1007/BF00177425.
Sixty-six children with intrinsic brainstem gliomas diagnosed between 1980 and 1986 underwent radical surgical resection. Retrospective analysis permitted classification of tumors into four categories: diffuse, focal, cystic and cervicomedullary. All 27 patients with diffuse tumors had malignant neoplasms, were not benefitted by surgery and died within 12-18 months. Five of nine cystic tumors, three of five focal tumors and twenty of twenty-four cervicomedullary tumors had low grade histopathology and are alive one to six years postoperatively. The authors propose a clinical-neuroradiological criteria that accurately predict which patients with brainstem tumors are likely to benefit from radical surgical intervention.
1980年至1986年间诊断为脑干原发性胶质瘤的66名儿童接受了根治性手术切除。回顾性分析将肿瘤分为四类：弥漫性、局灶性、囊性和颈髓性。所有27例弥漫性肿瘤患者均为恶性肿瘤，手术未使其受益，在12至18个月内死亡。9例囊性肿瘤中有5例、5例局灶性肿瘤中有3例以及24例颈髓性肿瘤中有20例组织病理学分级较低，术后存活1至6年。作者提出了一种临床神经放射学标准，可准确预测哪些脑干肿瘤患者可能从根治性手术干预中受益。
