Farash Bibi Razieh Hosseini, Shamsian Seyed Ali Akbar, Mohajery Masoud, Fata Abdolmajid, Sadabadi Fatemeh, Berenji Fariba, Mastroeni Pietro, Poustchi Elham, Moghaddas Elham, Sangani Ghodratollah Salehi, Farnoosh Gholamreza
Mashhad University of Medical Sciences Faculty of Medicine, Department of Parasitology and Mycology, Mashhad, Iran
Tehran University of Medical Sciences Faculty of Public Health, Department of Parasitology and Mycology, Tehran, Iran
Turkiye Parazitol Derg. 2020 Mar 20;44(1):52-57. doi: 10.4274/tpd.galenos.2019.6137.
The province of Khorasan-Razavi in the North East of Iran is an endemic area for anthroponotic cutaneous leishmaniasis (ACL caused mainly by ) and zoonotic cutaneous leishmaniasis (ZCL caused mainly by ). Based on clinical signs, some cities were considered as ACL foci while others were considered to be endemic for ZCL. This paper reviews studies performed on patients diagnosed with cutaneous leishmaniasis (CL) via the use of direct slide examination, ELISA, electrophoresis isoenzyme, RAPD PCR and PCR in Mashhad; the study also includes cases of CL in other cities of the Khorasan-Razavi province where only PCR used as a diagnostic tool. The data show that both and caused CL in most of the cities investigated. Our review shows that was found in areas where ACL is prevalent and was observed in areas with high incidence of ZCL. This distribution represents a major change in the epidemiological pattern of Leishmania in the Khorasan-Razavi province.
伊朗东北部的霍拉桑-拉扎维省是皮肤利什曼病（主要由 引起的人源性皮肤利什曼病，简称ACL）和动物源性皮肤利什曼病（主要由 引起的动物源性皮肤利什曼病，简称ZCL）的流行地区。根据临床症状，一些城市被视为ACL疫源地，而其他城市则被认为是ZCL的流行区。本文回顾了在马什哈德通过直接涂片检查、酶联免疫吸附测定（ELISA）、电泳同工酶、随机扩增多态性DNA聚合酶链反应（RAPD PCR）和聚合酶链反应（PCR）对诊断为皮肤利什曼病（CL）的患者进行的研究；该研究还包括霍拉桑-拉扎维省其他城市的CL病例，在这些城市中仅将PCR用作诊断工具。数据显示，在大多数调查的城市中， 和 均引起CL。我们的综述表明， 在ACL流行地区被发现，而 在ZCL高发地区被观察到。这种分布代表了霍拉桑-拉扎维省利什曼原虫流行病学模式的重大变化。 （注：原文中部分关键致病原虫名称未完整给出，翻译时保留了英文缩写）
