Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, People's Republic of China.
Department of Microbiology and Immunology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Emerg Microbes Infect. 2020 Dec;9(1):771-774. doi: 10.1080/22221751.2020.1747950.
We report a case of a 63-year-old female patient who developed a recurrent urinary tract infection (UTI) with extensively drug-resistant (ERKp). In the initial two rounds of phage therapy, phage resistant mutants developed within days. Although ERKp strains were completely resistant to sulfamethoxazole-trimethoprim, the combination of sulfamethoxazole-trimethoprim with the phage cocktail inhibited the emergence of phage resistant mutant , and the UTI of patient was successfully cured by this combination. Thus, we propose that non-active antibiotic and bacteriophage synergism (NABS) might be an alternative strategy in personalized phage therapy.
我们报告了一例 63 岁女性患者，她反复发生广泛耐药性（ERKp）尿路感染（UTI）。在最初的两轮噬菌体治疗中，噬菌体耐药突变株在数天内就出现了。尽管 ERKp 菌株对磺胺甲恶唑-甲氧苄啶完全耐药，但磺胺甲恶唑-甲氧苄啶与噬菌体鸡尾酒的联合使用抑制了噬菌体耐药突变株的出现，并且该联合治疗成功治愈了患者的 UTI。因此，我们提出非活性抗生素和噬菌体协同作用（NABS）可能是个性化噬菌体治疗的一种替代策略。
