School of Life Science and Technology, Tokyo Institute of Technology, 4259 J2-15 Nagatsuta-cho, Midori-ku, Yokohama, 226-8501, Japan.
Appl Microbiol Biotechnol. 2019 Mar;103(5):2121-2131. doi: 10.1007/s00253-019-09629-x. Epub 2019 Jan 24.
Due to a constant attack by phage, bacteria in the environment have evolved diverse mechanisms to defend themselves. Several reviews on phage resistance mechanisms have been published elsewhere. Thanks to the advancement of molecular techniques, several new phage resistance mechanisms were recently identified. For the practical phage therapy, the emergence of phage-resistant bacteria could be an obstacle. However, unlike antibiotic, phages could evolve a mechanism to counter-adapt against phage-resistant bacteria. In this review, we summarized the most recent studies of the phage-bacteria arm race with the perspective of future applications of phages as antimicrobial agents.
由于噬菌体的持续攻击，环境中的细菌已经进化出多种防御机制。噬菌体抗性机制的几篇综述已在其他地方发表。由于分子技术的进步，最近又发现了几种新的噬菌体抗性机制。对于实际的噬菌体治疗来说，噬菌体抗性细菌的出现可能是一个障碍。然而，与抗生素不同，噬菌体可以进化出一种机制来对抗噬菌体抗性细菌。在这篇综述中，我们总结了噬菌体-细菌军备竞赛的最新研究，从噬菌体作为抗菌剂的未来应用的角度来看待这个问题。
