酸性蛋白酶之间的同源性：华根霉和寄生内座壳酸性蛋白酶3埃分辨率晶体结构的比较
Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica.
作者信息
Subramanian E, Swan I D, Liu M, Davies D R, Jenkins J A, Tickle I J, Blundell T L
出版信息
Proc Natl Acad Sci U S A. 1977 Feb;74(2):556-9. doi: 10.1073/pnas.74.2.556.
Abstract
The molecular structures of two fungal acid proteases at 3 A resolution have been compared, and found to have similar secondary and tertiary folding. These enzymes are bilobal and have a pronounced cleft between the two lobes. This cleft has been identified as the active site region from inhibitor binding studies. The results of the comparison are discussed in terms of homology among the acid proteases in general.
摘要
已对两种真菌酸性蛋白酶在3埃分辨率下的分子结构进行了比较，发现它们具有相似的二级和三级折叠结构。这些酶呈双叶状，两叶之间有明显的裂隙。根据抑制剂结合研究，已确定该裂隙为活性位点区域。总体上，将根据酸性蛋白酶之间的同源性对比较结果进行讨论。
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