糖皮质激素诱导淋巴细胞溶解的钙依赖性
Calcium dependence of glucocorticoid-induced lymphocytolysis.
作者信息
Kaiser N, Edelman I S
出版信息
Proc Natl Acad Sci U S A. 1977 Feb;74(2):638-42. doi: 10.1073/pnas.74.2.638.
Abstract
A potent glucocorticoid, triamcinolone acetonide (9alpha-fluoro-11beta, 16alpha,17alpha, 21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide) and a divalent cation ionophore (A23187) had similar effects in vitro on [3H]uridine uptake and on lysis of thymocytes of adrenalectomized rats. Removal of Ca2+ from the medium blunted the cytolytic action of triamcinolone acetonide and virtually eliminated that of A23187. In Ca2+-free media, treatment of the thymocytes for 15 hr with triamcinolone acetonide or A23187 followed by re-introduction of Ca2+ resulted in a rapid decrease in cell survival. Based on the time courses of the responses, triamcinolone acetonide and A23187 evoked proportionate increases in 45Ca uptake and lysis of the thymocytes. These findings implicate enhanced Ca2+ uptake in glucocorticoid-dependent lymphocytolysis.
摘要
强效糖皮质激素曲安奈德（9α-氟-11β，16α，17α，21-四羟基孕甾-1,4-二烯-3,20-二酮-16,17-缩丙酮）和二价阳离子离子载体（A23187）在体外对去肾上腺大鼠胸腺细胞的[3H]尿苷摄取和裂解具有相似的作用。从培养基中去除Ca2+会减弱曲安奈德的细胞溶解作用，并几乎消除A23187的细胞溶解作用。在无Ca2+的培养基中，用曲安奈德或A23187处理胸腺细胞15小时后再重新加入Ca2+，会导致细胞存活率迅速下降。根据反应的时间进程，曲安奈德和A23187引起胸腺细胞45Ca摄取和裂解成比例增加。这些发现表明糖皮质激素依赖性淋巴细胞溶解过程中Ca2+摄取增加。
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