Frequency-domain CBE imaging for ultrasound localization of the HIFU focal spot: a feasibility study.

High-intensity focused ultrasound (HIFU) is a well-accepted tool for noninvasive thermal therapy. To control the quality of HIFU treatment, the focal spot generated in tissues must be localized. Ultrasound imaging can monitor heated regions; in particular, the change in backscattered energy (CBE) allows parametric imaging to visualize thermal information in the tissue. Conventional CBE imaging constructed in the spatial domain may be easily affected by noises when the HIFU focal spot is visualized. This study proposes frequency-domain CBE imaging to improve noise tolerance and image contrast in HIFU focal spot monitoring. Phantom experiments were performed in a temperature-controlled environment. HIFU of 2.12 MHz was applied to the phantoms, during which a clinical scanner equipped with a 3-MHz convex array transducer was used to collect raw image data consisting of backscattered signals for B-mode, spatial-, and frequency-domain CBE imaging. Concurrently, temperature changes were measured at the focal spot using a thermocouple for comparison with CBE values by calculating the correlation coefficient r. To further analyze CBE image contrast levels, a contrast factor was introduced, and an independent t-test was performed to calculate the probability value p. Experimental results showed that frequency-domain CBE imaging performed well in thermal distribution visualization, enabling quantitative detection of temperature changes. The CBE value calculated in the frequency domain also correlated strongly with that obtained using the conventional spatial-domain approach (r = 0.97). In particular, compared with the image obtained through the conventional method, the contrast of the CBE image obtained using the method based on frequency-domain analysis increased by 2.5-fold (4 dB; p < 0.05). Frequency-domain computations may constitute a new strategy when ultrasound CBE imaging is used to localize the focal spot in HIFU treatment planning.