Ma Shao, Lv Yanrong, Ma Rong
Department of Breast Surgery, QiLu Hospital of Shandong University, Jinan 250012, Shandong, People's Republic of China.
Cancer Manag Res. 2020 Mar 13;12:1895-1901. doi: 10.2147/CMAR.S239085. eCollection 2020.
The metastatic lymph node ratio (MLNR) is one of the most important factors in prognostic analysis of breast cancer. The objective of this study was to determine if MLNR combined with protein-tyrosine phosphatase H1 (PTPH1) pathological expression can be used to predict the prognosis of patients with breast invasive ductal carcinoma (IDC) better than one factor only.
A total of 136 patients with invasive ductal carcinoma (IDC) of breast who underwent modified radical mastectomy and were treated with chemotherapy after operation at Qilu Hospital of Shandong University from December 2008 to October 2011 were included. PTPH1 expression was evaluated by immunohistochemistry in surgical specimens retrospectively collected from patients with histologically proven invasive ductal breast cancer. Kaplan-Meier survival analysis and Cox regression analysis were performed to assess the prognostic significance of PTPH1 expression. A prognostic factor for disease-free survival (DFS) was identified by univariate and multivariate analyses. ROC analysis was used to evaluate the performance of single factors and combined feature.
One hundred and thirty-six patients were included in the analysis. By cut-point survival analysis, MLNR cut-off was designed as 0.2. On multivariate analysis, a MLNR>0.2 was associated with a worse DFS (HR=2.581, 95% CI=1.303-5.113, =0.007). PTPH1 overexpression is correlated with a better DFS (HR=0.391, 95% CI=0.162-0.945, =0.037). In addition, MLNR and PTPH1 combined feature had better performance in predicting clinical outcomes after surgery long before recurrence had occurred (Area under the curve=0.795 [95% CI=0.694-0.896], <0.001).
These findings indicate that both PTPH1 and MLNR are accurate independent prognostic parameters in patients with IDC of the breast. Better information on IDC prognosis could be obtained from the combined feature.
转移淋巴结比率（MLNR）是乳腺癌预后分析中最重要的因素之一。本研究的目的是确定MLNR联合蛋白酪氨酸磷酸酶H1（PTPH1）的病理表达是否比单一因素能更好地预测乳腺浸润性导管癌（IDC）患者的预后。
纳入2008年12月至2011年10月在山东大学齐鲁医院接受改良根治性乳房切除术并术后接受化疗的136例乳腺浸润性导管癌（IDC）患者。通过免疫组织化学回顾性分析从经组织学证实为浸润性导管乳腺癌患者手术标本中评估PTPH1表达。进行Kaplan-Meier生存分析和Cox回归分析以评估PTPH1表达的预后意义。通过单因素和多因素分析确定无病生存（DFS）的预后因素。采用ROC分析评估单因素和联合特征的性能。
136例患者纳入分析。通过切点生存分析，将MLNR切点设定为0.2。多因素分析显示，MLNR>0.2与较差的DFS相关（HR=2.581，95%CI=1.303-5.113，P=0.007）。PTPH1过表达与较好的DFS相关（HR=0.39
