雌性犬混合型癌侵袭区域的数量和大小与区域转移相关。
The Number and Size of Invasion Areas in Mixed-Type Carcinoma in Female Dogs Are Associated with Regional Metastases.
作者信息
Miranda Fernanda Freitas, Garcia Ana Paula Vargas, Dos Reys Marina Possa, Viscone Erica Almeida, Flecher Mayra Cunha, Rodrigues Michele Angela, Cassali Geovanni Dantas
机构信息
Department of General Pathology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil.
Veterinary Diagnostic Center, Celulavet, Belo Horizonte 31365-000, MG, Brazil.
出版信息
Vet Sci. 2025 Mar 31;12(4):318. doi: 10.3390/vetsci12040318.
Mixed-type carcinoma (MTC) accounts for 44% of mammary neoplasms in bitches and poses challenges in histological grading due to the heterogeneity of invasive areas. The present study aimed to measure and characterize invasive areas in the stroma of MTC and investigate the association of those parameters with lymph node status and survival. Forty cases were analyzed and divided into two groups: with metastasis and without metastasis. The size, perimeter, length, and number of invasive carcinomatous areas were measured. Cases with metastasis showed a higher number of foci ( = 0.003) and larger invasive areas ( = 0.006) compared to cases without metastasis. Bitches with invasive areas larger than 2 mm had shorter survival times. No association was found between the perimeter or length of invasive areas, the expression of Ki67, ER, PR, COX-2, HER-2, and the immunophenotype. Thus, the number and size of invasive areas are associated with regional lymph node status, suggesting histomorphometry may serve as a valuable tool for evaluating the biological behavior of mixed-type carcinoma.
混合型癌（MTC）占母犬乳腺肿瘤的44%，由于浸润区域的异质性，在组织学分级方面存在挑战。本研究旨在测量和表征MTC基质中的浸润区域，并研究这些参数与淋巴结状态和生存的关系。分析了40例病例，并将其分为两组：有转移组和无转移组。测量了浸润癌区域的大小、周长、长度和数量。与无转移病例相比，有转移病例的病灶数量更多（P = 0.003），浸润区域更大（P = 0.006）。浸润区域大于2 mm的母犬生存时间较短。未发现浸润区域的周长或长度、Ki67、ER、PR、COX-2、HER-2的表达与免疫表型之间存在关联。因此，浸润区域的数量和大小与区域淋巴结状态相关，提示组织形态计量学可能是评估混合型癌生物学行为的有价值工具。
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