Mahdavi Nazanin, Ghorbanpour Maedeh
Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Iran J Pathol. 2020 Spring;15(2):144-150. doi: 10.30699/ijp.2020.105039.2076. Epub 2019 Dec 26.
Epithelial-myoepithelial carcinoma (EMC) is considered as a rare malignant salivary gland neoplasm with good prognosis, low recurrence rate and rare metastasis. Here we present a case of epithelial-myoepithelial carcinoma in a 42-year-old female with a swelling of 3-year duration in her palate. Histopathologic evaluation of the lesion demonstrated a well-circumscribed, biphasic salivary gland tumor composed of double-layered ductal/glandular structures, composed of small luminal eosinophilic cells and abluminal larger clear myoepithelial cells, and luminal cells were positive for pan-cytokeratin, while the abluminal cells exhibited strong immunoreactivity for p63. Ki-67 proliferative index was 1% in abluminal cells. In this article, histopathologic and immunohistochemical features of EMC and its mimics are discussed and the previously reported cases of EMC in the literature are summarized.
上皮-肌上皮癌（EMC）被认为是一种罕见的唾液腺恶性肿瘤，预后良好，复发率低且转移罕见。在此，我们报告一例42岁女性的上皮-肌上皮癌，其腭部肿物已有3年。对该病变的组织病理学评估显示为一个边界清晰的双相性唾液腺肿瘤，由双层导管/腺管结构组成，内层为嗜酸性小细胞，外层为较大的透明肌上皮细胞，内层细胞泛细胞角蛋白阳性，而外层细胞对p63呈强免疫反应性。外层细胞的Ki-67增殖指数为1%。本文讨论了EMC及其相似病变的组织病理学和免疫组化特征，并总结了文献中先前报道的EMC病例。
