前列腺癌中的PARP抑制剂联合疗法
PARP inhibitor combinations in prostate cancer.
作者信息
Pezaro Carmel
机构信息
University of Sheffield and Sheffield Teaching Hospitals NHS Foundation Trust, Whitham Road, Sheffield S10 2SJ, UK.
出版信息
Ther Adv Med Oncol. 2020 Mar 18;12:1758835919897537. doi: 10.1177/1758835919897537. eCollection 2020.
Abstract
Polyadenosine-diphosphate-ribose polymerase (PARP) inhibitors cause deoxyribonucleic acid (DNA) damage that can be lethal to cells with deficient repair mechanisms. A number of PARP inhibitors are being tested as treatments for men with prostate cancer, both as monotherapies and in combinations that are based on purported synergies in treatment effect. While the initial single-agent development focused on men with identified deficiencies in DNA-repair pathways, broader patient populations are being considered for combination approaches. This review summarizes the current clinical development of PARP inhibitors and explores the rationale for novel combination strategies.
摘要
聚腺苷二磷酸核糖聚合酶（PARP）抑制剂会导致脱氧核糖核酸（DNA）损伤，这对于修复机制存在缺陷的细胞可能是致命的。目前有多种PARP抑制剂正在作为前列腺癌男性患者的治疗方法进行测试，包括单药治疗以及基于所谓协同治疗效果的联合治疗。虽然最初的单药研发聚焦于已确定存在DNA修复途径缺陷的男性患者，但联合治疗方法正在考虑更广泛的患者群体。本综述总结了PARP抑制剂目前的临床研发情况，并探讨了新型联合策略的理论依据。
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