Ngan Nguyen Dinh, Cuong Nguyen Van, Trung Nguyen Le, Dat Dang Tran, Tuan Hoang Anh, Dong Pham Ngoc, Nga Vu Thi, Bac Nguyen Duy, Xuan Cung Le
Department of Ophthalmology, 103 Military Hospital, Hanoi, Vietnam.
Department of Ophthalmology, Vietnam Military Medical University, Hanoi, Vietnam.
Open Access Maced J Med Sci. 2019 Dec 20;7(24):4324-4328. doi: 10.3889/oamjms.2019.384. eCollection 2019 Dec 30.
Idiopathic epiretinal membrane (iERM) is an avascular proliferation of different types of cells between the posterior vitreous cortex and the internal limiting membrane. That causes visual impairment including blurry, distortion, scotoma. Many studies of iERM were done to describe the clinical characteristics and investigate the histopathology of this disease. Nonetheless, there has not been a study of iERM histopathology in Vietnam.
To describe clinical characteristics and histopathological results of idiopathic retinal membrane and the association between them.
A cross sectional decriptive study of 35 iERMs (33 patients) in Vietnam National Institute of Ophthalmology (VNIO).
High morbidity incidence was in group age >50 years (32/35), female gender (26/35), limited movement works (27/35), and high educational levels (28/35). Distortion was the highest (77.14%), scotoma and floater was less frequent (28.5%, 45.7%). Macular edema in all cases and PVD and exudate were high frequent (65.7%, 62.8%). Symptom duration was 8.2 ± 4.7 months, (1-21 months). Mean of central macular thickness was 468.51 ± 97.24 µm (656-274 µm). Six types of cell were detected, including glial cell (35/35), fibroblast (23/35), myofibroblast (23/35), macrophage (13/35), lymphocyte (5/35) and neutrophil (2/35). The number of cell types in one sample ranged from 1-5 types (2.85 ± 1.28 cell types). Number of cell types were correlated to symptom duration (r = 0.47, p = 0.004, Pearson's test) and central macular thickness (r = 0.72, p < 0.001, Pearson's test).
There were 6 types of cells in iERM. Glial cell was the most frequent cell, inflammatory cells (macrophage, lymphocyte, neutrophil) was also detected. The number of cell types was stastitically correlated to symptom duration and CMT.
特发性视网膜前膜（iERM）是一种位于玻璃体后皮质与内界膜之间的不同类型细胞的无血管增殖。这会导致视力损害，包括视物模糊、变形、暗点。许多关于iERM的研究旨在描述其临床特征并研究该疾病的组织病理学。然而，越南尚未有关于iERM组织病理学的研究。
描述特发性视网膜前膜的临床特征和组织病理学结果以及它们之间的关联。
在越南国家眼科研究所（VNIO）对35例iERM（33例患者）进行横断面描述性研究。
发病率较高的人群为年龄>50岁（32/35）、女性（26/35）、从事有限活动工作的人（27/35）以及高学历人群（28/35）。变形最为常见（77.14%），暗点和飞蚊症的发生率较低（分别为28.5%、45.7%）。所有病例均有黄斑水肿，玻璃体后脱离和渗出物的发生率较高（分别为65.7%、62.8%）。症状持续时间为8.2±4.7个月（1 - 21个月）。中心黄斑厚度平均值为468.51±97.24µm（656 - 274µm）。检测到六种类型的细胞，包括神经胶质细胞（35/35）、成纤维细胞（23/35）、肌成纤维细胞（23/35）、巨噬细胞（13/35）、淋巴细胞（5/35）和中性粒细胞（2/35）。一个样本中的细胞类型数量为1 - 5种（2.85±1.28种细胞类型）。细胞类型数量与症状持续时间（r = 0.47，p = 0.004，Pearson检验）和中心黄斑厚度（r = 0.72，p < 0.001，Pearson检验）相关。
iERM中有六种类型的细胞。神经胶质细胞是最常见的细胞，也检测到了炎症细胞（巨噬细胞、淋巴细胞、中性粒细胞）。细胞类型数量与症状持续时间和中心黄斑厚度存在统计学相关性。
