Nam Le Van, Quyet Do, Hung Pham Ngoc, Tien Tran Viet, Thanh Kieu Chi, Dung Quan Anh, Linh Do Dieu, Tan Ha The, Bac Nguyen Duy, Dinh Thien Chu, Pho Dinh Cong
Department of Infectious Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.
Director of Vietnam Military Medical University, Department of Tuberculosis and Lung Diseases, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.
Open Access Maced J Med Sci. 2019 Dec 20;7(24):4406-4410. doi: 10.3889/oamjms.2019.871. eCollection 2019 Dec 30.
Evaluating the antibiotic susceptibility and resistance genes is essential in the clinical management of bloodstream infections (BSIs). Nevertheless, there are still limited studies in Northern Vietnam. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
This study aimed to determine the antibiotic resistance profile and methicillin-resistant encoding genes of Staphylococcus aureus (S. aureus) causing BSIs in Northern Vietnam.
The cross-sectional study was done from December 2012 to June 2014 in two tertiary hospitals in Northern Vietnam. Tests performed at the lab of the hospital.
In 43 S. aureus strains isolating, 53.5 % were MRSA. Distribution of gene for overall, MRSA, and MSSA strains were following mecA gene (58.1 %; 95.7%, and 15%), femA gene (48.8%, 47.8%, and 50%), femB gene (88.4%, 82.6%, and 95%). Antibiotic resistance was highest in penicillin (100%), followed by erythromycin (65.1%) and clindamycin (60.5%). Several antibiotics were susceptible (100%), including vancomycin, tigecycline, linezolid, quinupristin/dalfopristin. Quinolone group was highly sensitive, include ciprofloxacin (83.7%), levofloxacin (86%) and moxifloxacin (86%).
In S. aureus causing BSIs, antibiotic resistance was higher in penicillin, erythromycin, and clindamycin. All strains were utterly susceptible to vancomycin, tigecycline, linezolid, quinupristin/dalfopristin.
评估抗生素敏感性和耐药基因对于血流感染（BSIs）的临床管理至关重要。然而，越南北方的相关研究仍然有限。这是一篇根据知识共享署名-非商业性使用 4.0 国际许可协议（CC BY-NC 4.0）发布的开放获取文章。
本研究旨在确定引起越南北方血流感染的金黄色葡萄球菌（S. aureus）的抗生素耐药谱及耐甲氧西林编码基因。
这项横断面研究于 2012 年 12 月至 2014 年 6 月在越南北方的两家三级医院进行。检测在医院实验室进行。
在分离出的 43 株金黄色葡萄球菌菌株中，53.5%为耐甲氧西林金黄色葡萄球菌（MRSA）。总体、MRSA 和甲氧西林敏感金黄色葡萄球菌（MSSA）菌株的基因分布如下：mecA 基因（58.1%；95.7%和 15%）、femA 基因（48.8%、47.8%和 50%）、femB 基因（88.4%、82.6%和 95%）。抗生素耐药率最高的是青霉素（100%），其次是红霉素（65.1%）和克林霉素（60.5%）。几种抗生素的敏感性为 100%，包括万古霉素、替加环素、利奈唑胺、奎奴普丁/达福普汀。喹诺酮类药物高度敏感，包括环丙沙星（83.7%）、左氧氟沙星（86%）和莫西沙星（86%）。
在引起血流感染的金黄色葡萄球菌中，青霉素、红霉素和克林霉素的抗生素耐药率较高。所有菌株对万古霉素、替加环素、利奈唑胺、奎奴普丁/达福普汀完全敏感。
