Onodera K, Maeyama K, Watanabe T
Department of Pharmacology, Tohoku University School of Dentistry, Senda, Japan.
Jpn J Pharmacol. 1988 Jul;47(3):323-6. doi: 10.1254/jjp.47.323.
Histamine levels in thiamine deficient rats were significantly lower in the hippocampus, amygdala, olfactory bulb, thalamus and pons-medulla oblongata than those of normal and pair-fed groups. In the case of the hypothalamus, thiamine deficiency produced a significant increase in histamine levels. These changes observed in the thiamine deficient group were reversed to the normal levels by supplying the normal diet. These data present a new finding that thiamine deficiency affects the central histaminergic neuron system as well as other monoaminergic systems.
硫胺素缺乏大鼠海马体、杏仁核、嗅球、丘脑和脑桥 - 延髓中的组胺水平显著低于正常组和配对喂养组。在下丘脑，硫胺素缺乏导致组胺水平显著升高。在硫胺素缺乏组中观察到的这些变化通过提供正常饮食恢复到正常水平。这些数据呈现了一个新发现，即硫胺素缺乏会影响中枢组胺能神经元系统以及其他单胺能系统。
