Onodera K, Shinoda H, Watanabe T
Department of Pharmacology, Tohoku University School of Dentistry, Sendai, Japan.
Jpn J Pharmacol. 1990 Nov;54(3):339-43. doi: 10.1254/jjp.54.339.
The rats maintained on a thiamine-deficient diet for 30 days showed hypothermia, and their histamine levels increased significantly in both the anterior and posterior hypothalamus. When these rats were administered, thiamine disulfide and/or provided with thiamine-added diet for a further 30 days, the rats recovered from hypothermia, and histamine levels were decreased to the normal level. Thus, it is probable that the increased histamine levels in the hypothalamus, especially those in its anterior region, are closely related to the hypothermia in thiamine-deficient rats.
连续30天食用缺乏硫胺素饮食的大鼠出现体温过低，其下丘脑前部和后部的组胺水平均显著升高。当给这些大鼠再给予二硫化硫胺素和/或提供添加硫胺素的饮食30天时，大鼠从体温过低中恢复，组胺水平降至正常水平。因此，下丘脑组胺水平升高，尤其是其前部区域的组胺水平升高，可能与硫胺素缺乏大鼠的体温过低密切相关。
