Sugio K, Horigome N, Inami T, Tanaka Y, Sakurai M, Gotoh M, Sakaguchi T
Biological Science Department, Hoechst Japan, Ltd., Saitama.
Jpn J Pharmacol. 1988 Jul;47(3):327-9. doi: 10.1254/jjp.47.327.
The bilateral hemispheric ischemia in rats was induced by the occlusion of bilateral common carotid arteries after permanent electrocauterization of bilateral vertebral arteries at the level of the second cervical vertebra. In ischemic rats, (a) electroencephalograms became flat immediately after occlusion of carotid arteries, and (b) mortalities reached maximum levels at day 3 after recirculation. These results suggested that a constant level of cerebral ischemia was produced in this rat model. Pentobarbital markedly inhibited the mortality in these ischemic rats, whereas cyproheptadine did not.
在大鼠第二颈椎水平永久性电灼双侧椎动脉后，通过阻断双侧颈总动脉诱导大鼠双侧半球缺血。在缺血大鼠中，(a) 阻断颈动脉后脑电图立即变平，且 (b) 再灌注后第3天死亡率达到最高水平。这些结果表明，该大鼠模型产生了恒定水平的脑缺血。戊巴比妥显著抑制这些缺血大鼠的死亡率，而赛庚啶则无此作用。
