Department of Plastic Surgery, Hospital das Clínicas - UFPE, Recife, Pernambuco, Brazil.
Division of Plastic Surgery, Baylor College of Medicine, Houston, TX.
Aesthet Surg J. 2020 May 16;40(6):NP388-NP393. doi: 10.1093/asj/sjz327.
Autologous fat graft is often employed to treat body contour defects. There is currently increased interest in the regenerative properties of fat grafting.
The authors evaluated the histological changes of fat grafting in a blinded randomized controlled trial of staged fat grafting-abdominoplasty.
Ten women between 24 and 55 years of age with a body mass index <30 kg/m2 and previous cesarean scar were submitted to fat grafting followed by staged abdominoplasty. The C-section scar served as a landmark for standardization of fat grafting site and control. One side of the abdomen was fat grafted and the other was left intact (control). At the time of abdominoplasty, 4 months later, a full-thickness skin sample from each hemi abdomen (fat-grafted area and control) was collected and sent to histological analysis.
All of the fat-grafted samples showed extracellular lipids and signs of fat graft viability, whereas no such changes occurred in the control group. There were no statistically significant differences in fat-grafted vs control samples regarding skin inflammatory infiltrate (P = 0.582), dermis thickness (P = 0.973), vascular density (P = 0.326), and amount of elastic fibers (P = 1).
The histological evaluation of women's abdominoplasty surgical site skin after 4 months of fat grafting showed signs of fat graft in 100% of the grafted sides but no change in skin inflammatory infiltrate, dermis thickness, vascularity density, or elastic fiber quantity.
自体脂肪移植常用于治疗身体轮廓缺陷。目前，人们对脂肪移植的再生特性越来越感兴趣。
作者通过分期脂肪移植-腹部整形术的盲法随机对照试验，评估脂肪移植的组织学变化。
10 名年龄在 24 至 55 岁之间、体重指数<30kg/m2 且有剖宫产瘢痕的女性接受了脂肪移植，随后进行分期腹部整形术。剖宫产瘢痕作为脂肪移植部位和对照的标准化标志物。一侧腹部进行脂肪移植，另一侧保持完整（对照）。4 个月后，在进行腹部整形术时，从每个半腹部（脂肪移植区和对照区）采集全层皮肤样本并进行组织学分析。
所有脂肪移植样本均显示细胞外脂质和脂肪移植存活的迹象，而对照组则没有这种变化。脂肪移植与对照组样本在皮肤炎症浸润（P=0.582）、真皮厚度（P=0.973）、血管密度（P=0.326）和弹性纤维数量（P=1）方面均无统计学差异。
对女性腹部整形术后 4 个月的手术部位皮肤进行组织学评估，发现 100%的移植侧有脂肪移植的迹象，但皮肤炎症浸润、真皮厚度、血管密度或弹性纤维数量均无变化。
