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老年女性早期乳腺癌外科腋窝管理的趋势:过度治疗仍在继续。

Trends in Surgical Axillary Management in Early Stage Breast Cancer in Elderly Women: Continued Over-Treatment.

机构信息

Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

出版信息

Ann Surg Oncol. 2020 Sep;27(9):3426-3433. doi: 10.1245/s10434-020-08388-8. Epub 2020 Mar 25.


DOI:10.1245/s10434-020-08388-8
PMID:32215758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7415703/
Abstract

INTRODUCTION: In the past two decades, three prospective randomized trials demonstrated that elderly women with early stage hormone positive breast cancer had equivalent disease-specific mortality regardless of axillary surgery. In 2016, the Choosing Wisely campaign encouraged patients and providers to reconsider the role of axillary surgery in this population. We sought to identify factors that contribute to adopting non-operative management of the axilla in these patients. MATERIALS AND METHODS: We performed a retrospective analysis of women ≥ 70 years old with cT1/T2, hormone positive invasive ductal carcinoma who underwent partial or total mastectomy, with/without axillary surgery, and did not receive adjuvant chemotherapy from the National Cancer Database from 2004 to 2015. We used multivariable log-binomial regression to model the risk of undergoing axillary surgery across region, care setting, and Charlson-Deyo scores, and analyzed temporal trends using Poisson regression. From 2004 to 2015, 87,342 of 99,940 women who met inclusion criteria (83%) had axillary surgery. Over time, axillary surgery increased from 78% to 88% (p < 0.001). This rise was consistent across region (p = 0.81) and care setting (p = 0.09), but flattened as age increased (p < 0.001). Omitting axillary surgery was more likely in patients treated in New England (RR 0.88, 95% CI 0.86, 0.89) and patients ≥ 85 (RR 0.66, 95% CI 0.65, 0.67). CONCLUSIONS: Axillary surgery continues to be the preferred option of axillary management in elderly women with early stage, clinically node negative, hormone-positive, invasive breast cancer despite no survival benefit. Identifying factors to improve patient selection and dissemination of current recommendations can improve adoption of current evidence on axillary surgery in the elderly.

摘要

简介:在过去的二十年中,三项前瞻性随机试验表明,患有早期激素阳性乳腺癌的老年女性无论是否接受腋窝手术,其疾病特异性死亡率均相当。2016 年,明智选择运动鼓励患者和医务人员重新考虑在该人群中腋窝手术的作用。我们试图确定导致这些患者采用非手术方式管理腋窝的因素。

材料和方法:我们对 2004 年至 2015 年期间,国家癌症数据库中年龄≥70 岁、患有 cT1/T2 激素阳性浸润性导管癌、行部分或全乳房切除术、伴或不伴腋窝手术且未接受辅助化疗的女性进行了回顾性分析。我们使用多变量二项式回归模型来分析区域、护理环境和 Charlson-Deyo 评分对接受腋窝手术的风险,并使用泊松回归分析时间趋势。2004 年至 2015 年,符合纳入标准的 99,940 名女性中有 87,342 名(83%)接受了腋窝手术。随着时间的推移,腋窝手术的比例从 78%增加到 88%(p<0.001)。这种上升在各地区(p=0.81)和护理环境(p=0.09)中是一致的,但随着年龄的增长而趋于平稳(p<0.001)。在新英格兰地区(RR 0.88,95%CI 0.86,0.89)和≥85 岁的患者(RR 0.66,95%CI 0.65,0.67)中,省略腋窝手术的可能性更大。

结论:尽管对生存没有获益,但在患有早期临床淋巴结阴性、激素阳性、浸润性乳腺癌的老年女性中,腋窝手术仍然是首选的腋窝管理方法。确定可以改善患者选择和当前腋窝手术推荐意见传播的因素,有助于提高对老年人腋窝手术的当前证据的采用。

相似文献

[1]
Trends in Surgical Axillary Management in Early Stage Breast Cancer in Elderly Women: Continued Over-Treatment.

Ann Surg Oncol. 2020-9

[2]
Variations in the management of the axilla in screen-detected ductal carcinoma in situ: evidence from the UK NHS breast screening programme audit of screen detected DCIS.

Eur J Surg Oncol. 2014-10-16

[3]
Analysis of Surgical Trends for Axillary Lymph Node Management in Patients with Ductal Carcinoma In Situ Using the NSQIP Database: Are We Following National Guidelines?

Ann Surg Oncol. 2020-9

[4]
The Influence of Hospital and Surgeon Factors on the Prevalence of Axillary Lymph Node Evaluation in Ductal Carcinoma In Situ.

JAMA Oncol. 2015-6

[5]
Nodal positivity decreases with age in women with early-stage, hormone receptor-positive breast cancer.

Cancer. 2019-12-20

[6]
The Association of Extent of Axillary Surgery and Survival in Women with N2-3 Invasive Breast Cancer.

Ann Surg Oncol. 2018-7-5

[7]
Sentinel lymph node biopsy in women over 70: Evaluation of rates of axillary staging and impact on adjuvant therapy in elderly women.

Surgery. 2023-3

[8]
Identification of Populations at Risk for "Choosing Un-Wisely": A SEER Population-Based Study.

Am Surg. 2023-10

[9]
De-escalation of axillary surgery in breast cancer patients treated in the neoadjuvant setting: a Dutch population-based study.

Breast Cancer Res Treat. 2020-3-16

[10]
Population-based analysis of non-operative management and treatment patterns in older women with estrogen receptor-positive breast cancer.

Breast Cancer Res Treat. 2021-12

引用本文的文献

[1]
Feasibility of the omission of axillary surgery in node-negative early breast cancer: a systematic review and meta-analysis.

Breast. 2025-8-22

[2]
Regional Variation in Deescalated Therapy in Older Adults With Early-Stage Breast Cancer.

JAMA Netw Open. 2024-10-1

[3]
An Annual Symposium on Disparities in Milwaukee, WI, with a 2023 Focus on Older Adults with Cancer.

Curr Oncol Rep. 2024-8

[4]
Physician-level variation in axillary surgery in older adults with T1N0 hormone receptor-positive breast cancer: A retrospective population-based cohort study.

J Geriatr Oncol. 2024-6

[5]
Avoiding Locoregional Overtreatment in Older Adults With Early-Stage Breast Cancer.

Clin Breast Cancer. 2024-6

[6]
Impact of age on indication for chemotherapy in early breast cancer patients: results from 104 German institutions from 2008 to 2017.

Arch Gynecol Obstet. 2023-7

[7]
Assessment of Oncologists' Perspectives on Omission of Sentinel Lymph Node Biopsy in Women 70 Years and Older With Early-Stage Hormone Receptor-Positive Breast Cancer.

JAMA Netw Open. 2022-8-1

[8]
Neighborhood socioeconomic status and low-value breast cancer care.

J Surg Oncol. 2022-9

[9]
Variation in Deescalated Axillary Surgical Practices in Older Women with Early-Stage Breast Cancer.

Ann Surg Oncol. 2022-4-6

[10]
The impact of age and nodal status on variations in oncotype DX testing and adjuvant treatment.

NPJ Breast Cancer. 2022-3-1

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