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老年 T1N0 激素受体阳性乳腺癌患者腋窝手术中医生水平的差异:一项回顾性基于人群的队列研究。

Physician-level variation in axillary surgery in older adults with T1N0 hormone receptor-positive breast cancer: A retrospective population-based cohort study.

机构信息

Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, United States of America; Breast Oncology Program, Dana-Farber Brigham Cancer Center, Boston, MA, United States of America; Harvard Medical School, Boston, MA, United States of America; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA, United States of America.

Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA, United States of America.

出版信息

J Geriatr Oncol. 2024 Jun;15(5):101795. doi: 10.1016/j.jgo.2024.101795. Epub 2024 May 16.


DOI:10.1016/j.jgo.2024.101795
PMID:38759256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11225423/
Abstract

INTRODUCTION: We sought to determine how considerations specific to older adults impact between- and within-surgeon variation in axillary surgery use in women ≥70 years with T1N0 HR+ breast cancer. MATERIALS AND METHODS: Females ≥70 years with T1N0 HR+/HER2-negative breast cancer diagnosed from 2013 to 2015 in SEER-Medicare were identified and linked to the American Medical Association Masterfile. The outcome of interest was axillary surgery. Key patient-level variables included the Charlson Comorbidity Index (CCI) score, frailty (based on a claims-based frailty index score), and age (≥75 vs <75). Multilevel mixed models with surgeon clusters were used to estimate the intracluster correlation coefficient (ICC) (between-surgeon variance), with 1-ICC representing within-surgeon variance. RESULTS: Of the 4410 participants included, 6.1% had a CCI score of ≥3, 20.7% were frail, and 58.3% were ≥ 75 years; 86.1% underwent axillary surgery. No surgeon omitted axillary surgery in all patients, but 42.3% of surgeons performed axillary surgery in all patients. In the null model, 10.5% of the variance in the axillary evaluation was attributable to between-surgeon differences. After adjusting for CCI score, frailty, and age in mixed models, between-surgeon variance increased to 13.0%. DISCUSSION: In this population, axillary surgery varies more within surgeons than between surgeons, suggesting that surgeons are not taking an "all-or-nothing" approach. Comorbidities, frailty, and age accounted for a small proportion of the variation, suggesting nuanced decision-making may include additional, unmeasured factors such as differences in surgeon-patient communication.

摘要

简介:我们旨在确定老年人特有的考虑因素如何影响 70 岁及以上 T1N0 HR+乳腺癌女性中腋窝手术使用的术间和术内差异。 材料与方法:从 2013 年至 2015 年,SEER-Medicare 中确定并链接到美国医学协会主文件的 T1N0 HR+/HER2 阴性乳腺癌≥70 岁的女性患者,将腋窝手术作为观察结局。关键的患者水平变量包括 Charlson 合并症指数(CCI)评分、虚弱(基于索赔的虚弱指数评分)和年龄(≥75 岁与<75 岁)。使用带有外科医生聚类的多级混合模型估计组内相关系数(ICC)(外科医生间方差),1-ICC 代表外科医生内方差。 结果:在 4410 名参与者中,6.1%的患者 CCI 评分≥3,20.7%的患者虚弱,58.3%的患者≥75 岁;86.1%的患者接受了腋窝手术。没有外科医生在所有患者中都不进行腋窝手术,但 42.3%的外科医生对所有患者进行了腋窝手术。在零模型中,腋窝评估的 10.5%差异归因于外科医生间的差异。在混合模型中调整 CCI 评分、虚弱和年龄后,外科医生间的差异增加到 13.0%。 讨论:在该人群中,腋窝手术在外科医生之间的差异大于外科医生内的差异,这表明外科医生没有采取“全有或全无”的方法。合并症、虚弱和年龄仅占差异的一小部分,这表明精细的决策可能包括其他未测量的因素,例如外科医生与患者沟通的差异。

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引用本文的文献

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JAMA Netw Open. 2024-10-1

本文引用的文献

[1]
Is Choosing Wisely Wise for Lobular Carcinoma in Patients Over 70 Years of Age? A National Cancer Database Analysis of Sentinel Node Practice Patterns.

Ann Surg Oncol. 2023-10

[2]
NCCN Guidelines® Insights: Breast Cancer, Version 4.2023.

J Natl Compr Canc Netw. 2023-6

[3]
Current Trends in Volume and Surgical Outcomes in Gastric Cancer.

J Clin Med. 2023-4-4

[4]
Surgeon Factors Influencing Breast Surgery Outcomes: A Scoping Review to Define the Modern Breast Surgical Oncologist.

Ann Surg Oncol. 2023-8

[5]
Hepatopancreatic Surgeons Versus Pancreatic Surgeons: Does Surgical Subspecialization Impact Patient Care and Outcomes?

J Gastrointest Surg. 2023-4

[6]
The relationship of hospital and surgeon volume indicators and post-operative outcomes in pancreatic surgery: a systematic literature review, meta-analysis and guidance for valid outcome assessment.

HPB (Oxford). 2023-4

[7]
The impact of gender patient-physician concordance on interpersonal processes of care and patients' outcomes in the diabetes care setting.

Patient Educ Couns. 2023-1

[8]
Assessment of Oncologists' Perspectives on Omission of Sentinel Lymph Node Biopsy in Women 70 Years and Older With Early-Stage Hormone Receptor-Positive Breast Cancer.

JAMA Netw Open. 2022-8-1

[9]
Cost-effectiveness of Choosing Wisely guidelines for axillary observation in women older than age 70 years with hormone receptor-positive, clinically node-negative, operable breast tumors.

Cancer. 2022-6-15

[10]
Variation in Deescalated Axillary Surgical Practices in Older Women with Early-Stage Breast Cancer.

Ann Surg Oncol. 2022-4-6

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