文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

Variation in Deescalated Axillary Surgical Practices in Older Women with Early-Stage Breast Cancer.

作者信息

Minami Christina A, Jin Ginger, Schonberg Mara A, Freedman Rachel A, King Tari A, Mittendorf Elizabeth A

机构信息

Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Breast Oncology Program, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA.

出版信息

Ann Surg Oncol. 2022 Apr 6. doi: 10.1245/s10434-022-11677-z.


DOI:10.1245/s10434-022-11677-z
PMID:35385998
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9982465/
Abstract

BACKGROUND: Randomized controlled trials show that certain axillary surgical practices can be safely deescalated in older adults with early-stage breast cancer. Hospital volume is often equated with surgical quality, but it is unclear whether this includes performance of low-value surgeries. We sought to describe how utilization of two low-value axillary surgeries has varied by time and hospital volume. METHODS: Women aged ≥ 70 years diagnosed with breast cancer from 2013 to 2016 were identified in the National Cancer Database. The outcomes of interest were sentinel lymph node biopsy (SLNB) in cT1N0 hormone receptor-positive cancer patients and axillary lymph node dissection (ALND) in cT1-2N0 patients undergoing breast-conserving surgery with ≤ 2 pathologically positive nodes. Time trends in procedure use and multivariable regression with restricted cubic splines were performed, adjusting for patient, disease, and hospital factors. RESULTS: Overall, 83.4% of 44,779 women eligible for omission of SLNB underwent SLNB and 20.0% of 7216 patients eligible for omission of ALND underwent ALND. SLNB rates did not change significantly over time and remained significantly different by age group (70-74 years: 93.5%; 75-79 years: 89.7%, 80-84 years: 76.7%, ≥ 85 years: 48.9%; p < 0.05). ALND rates decreased over the study period across all age groups included (22.5 to 16.9%, p < 0.001). In restricted cubic splines models, lower hospital volume was associated with higher likelihood of undergoing SLNB and ALND. CONCLUSIONS: ALND omission has been more widely adopted than SLNB omission in older adults, but lower hospital volume is associated with higher likelihood of both procedures. Practice-specific deimplementation strategies are needed, especially for lower-volume hospitals.

摘要

相似文献

[1]
Variation in Deescalated Axillary Surgical Practices in Older Women with Early-Stage Breast Cancer.

Ann Surg Oncol. 2022-4-6

[2]
The State of Surgical Axillary Management and Adjuvant Radiotherapy for Early-stage Invasive Breast Cancer in the Modern Era.

Clin Breast Cancer. 2017-9-19

[3]
Patterns of completion axillary dissection for patients with cT1-2N0 breast cancer undergoing total mastectomy with positive sentinel lymph nodes.

J Surg Oncol. 2024-3

[4]
Axillary lymph node dissection can be omitted in patients with limited clinically node-positive breast cancer: a National Cancer Database analysis.

Br J Surg. 2022-11-22

[5]
Assessment of Oncologists' Perspectives on Omission of Sentinel Lymph Node Biopsy in Women 70 Years and Older With Early-Stage Hormone Receptor-Positive Breast Cancer.

JAMA Netw Open. 2022-8-1

[6]
Axillary treatment for operable primary breast cancer.

Cochrane Database Syst Rev. 2017-1-4

[7]
Questioning the role of axillary node dissection in sentinel node positive early stage breast cancer in the South Eastern Cancer Centre.

Ir J Med Sci. 2015-3

[8]
Comparative Study between Sentinel Lymph Node Biopsy and Axillary Dissection in Patients with One or Two Lymph Node Metastases.

J Breast Cancer. 2018-9

[9]
Trends in and outcomes from sentinel lymph node biopsy (SLNB) alone vs. SLNB with axillary lymph node dissection for node-positive breast cancer patients: experience from the SEER database.

Ann Surg Oncol. 2010-9-19

[10]
Axillary Lymph Node Dissection is Associated with Improved Survival Among Men with Invasive Breast Cancer and Sentinel Node Metastasis.

Ann Surg Oncol. 2023-9

引用本文的文献

[1]
Feasibility of the omission of axillary surgery in node-negative early breast cancer: a systematic review and meta-analysis.

Breast. 2025-8-22

[2]
Regional Variation in Deescalated Therapy in Older Adults With Early-Stage Breast Cancer.

JAMA Netw Open. 2024-10-1

[3]
An Annual Symposium on Disparities in Milwaukee, WI, with a 2023 Focus on Older Adults with Cancer.

Curr Oncol Rep. 2024-8

[4]
Physician-level variation in axillary surgery in older adults with T1N0 hormone receptor-positive breast cancer: A retrospective population-based cohort study.

J Geriatr Oncol. 2024-6

[5]
Avoiding Locoregional Overtreatment in Older Adults With Early-Stage Breast Cancer.

Clin Breast Cancer. 2024-6

本文引用的文献

[1]
Variations in Persistent Use of Low-Value Breast Cancer Surgery.

JAMA Surg. 2021-4-1

[2]
Trends in Surgical Axillary Management in Early Stage Breast Cancer in Elderly Women: Continued Over-Treatment.

Ann Surg Oncol. 2020-9

[3]
Barriers and Facilitators to De-Implementation of the Choosing Wisely Guidelines for Low-Value Breast Cancer Surgery.

Ann Surg Oncol. 2020-8

[4]
Nodal positivity decreases with age in women with early-stage, hormone receptor-positive breast cancer.

Cancer. 2019-12-20

[5]
Incident Cases Captured in the National Cancer Database Compared with Those in U.S. Population Based Central Cancer Registries in 2012-2014.

Ann Surg Oncol. 2019-2-8

[6]
Local Therapy Decisional Regret in Older Women With Breast Cancer: A Population-Based Study.

Int J Radiat Oncol Biol Phys. 2019-2-1

[7]
Axillary dissection versus no axillary dissection in patients with breast cancer and sentinel-node micrometastases (IBCSG 23-01): 10-year follow-up of a randomised, controlled phase 3 trial.

Lancet Oncol. 2018-9-5

[8]
Axillary Nodal Evaluation in Elderly Breast Cancer Patients: Potential Effects on Treatment Decisions and Survival.

Ann Surg Oncol. 2018-7-2

[9]
Improving antibiotic stewardship: a stepped-wedge cluster randomized trial.

Am J Manag Care. 2017-11-1

[10]
Patterns of axillary evaluation in older patients with breast cancer and associations with adjuvant therapy receipt.

Breast Cancer Res Treat. 2017-10-9

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索