[炎症性肠病男性患者勃起功能障碍的患病率：一项荟萃分析]

[Prevalence of erectile dysfunction in men with inflammatory bowel disease: A meta-analysis].

作者信息

Li Yun, Shi Lin, Zhang Jie, Liu Xiao-Wei

机构信息

Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.

Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.

出版信息

Zhonghua Nan Ke Xue. 2019 May;25(5):437-443.

PMID:32216231

Abstract

OBJECTIVE

To investigate the prevalence of ED in adult men with inflammatory bowel disease (IBD).

METHODS

We searched PubMed, Cochrane Library, EMbase, WanFang Database, and China National Knowledge Infrastructure (CNKI) Database for original articles relating the prevalence of ED among male IBD patients in the past 20 years, and performed meta-analysis on the identified studies.

RESULTS

A total of 9 eligible studies involving 734 cases of IBD were included, of which the pooled prevalence of ED was 34.4% (95% CI: 30.8－38.1). Subgroup analyses showed that the incidence rate of ED was significantly higher in the patients with Crohn's disease than in those with ulcerative colitis (36.3% ［95% CI: 30.1－42.9］ vs 26.8% ［95% CI: 21.9－32.3］, P < 0.05), and in those with active than in those with remissive IBD (47.6% ［95% CI: 38.3－57.2］ vs 26.4% ［95% CI: 22.0－31.4］, P < 0.05). The prevalence of ED was the lowest in the patients with ulcerative colitis after treated by ileal pouch-anal anastomosis (17.2% ［95% CI: 11.5－24.9］).

CONCLUSIONS

IBD is commonly associated with ED in male patients, and the risk of ED is increased in active IBD and decreased in remissive IBD.

摘要

目的

调查成年炎症性肠病（IBD）男性患者勃起功能障碍（ED）的患病率。

方法

我们检索了PubMed、Cochrane图书馆、EMbase、万方数据库和中国知网（CNKI）数据库，以查找过去20年中有关男性IBD患者ED患病率的原始文章，并对纳入的研究进行荟萃分析。

结果

共纳入9项符合条件的研究，涉及734例IBD患者，其中ED的合并患病率为34.4%（95%CI：30.8－38.1）。亚组分析显示，克罗恩病患者的ED发病率显著高于溃疡性结肠炎患者（36.3%［95%CI：30.1－42.9］对26.8%［95%CI：21.9－32.3］，P<0.05），IBD活动期患者的ED发病率高于缓解期患者（47.6%［95%CI：38.3－57.2］对26.4%［95%CI：22.0－31.4］，P<0.05）。经回肠储袋肛管吻合术治疗的溃疡性结肠炎患者的ED患病率最低（17.2%［95%CI：11.5－24.9］）。