Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, P. R. China.
Org Lett. 2020 Apr 17;22(8):3110-3113. doi: 10.1021/acs.orglett.0c00858. Epub 2020 Mar 27.
A -symmetric chiral spirocyclic diol -SPINOL containing a spirooxindole scaffold has been designed, synthesized, and optically resolved. The product could be synthesized on gram scale in an overall yield of 22%. Moreover, elaborations of -SPINOL to other chiral ligands as well as the preliminary investigation of the related bisphosphine ligand in the desymmetrization of bisallylic amide were reported.
设计、合成并拆分了具有螺噁唑吲哚骨架的非对映手性螺环二醇 -SPINOL。产物可以克级规模制备，总收率为 22%。此外，还对 -SPINOL 进行了衍生化，得到了其他手性配体，并初步研究了相关双膦配体在双烯丙基酰胺去对称化反应中的应用。
