通过镁催化环状和线性氨基甲酸酯的还原反应实现胺的甲基化和氘代甲基化。
-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates.
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
出版信息
Org Lett. 2020 Apr 17;22(8):3209-3214. doi: 10.1021/acs.orglett.0c00988. Epub 2020 Mar 27.
A new reduction of carbamates to -methyl amines is presented. The magnesium-catalyzed reduction reaction allows the conversion of cyclic and linear carbamates, including -Boc protected amines, into the corresponding -methyl amines and amino alcohols which are of significant interest due to their presence in many biologically active molecules. Furthermore, the reduction can be extended to the formation of -trideuteromethyl labeled amines.
现提出一种将氨基甲酸酯还原为 -甲基胺的新方法。该镁催化还原反应能够将环状和线性氨基甲酸酯（包括 -Boc 保护的胺）转化为相应的 -甲基胺和氨基醇，由于它们存在于许多生物活性分子中，因此具有重要意义。此外，该还原反应还可以扩展到 -三氘甲基标记胺的形成。
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