Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, Slovakia; Institute of Experimental Endocrinology, Biomedical Research Center of the Slovak Academy of Sciences, Bratislava, Slovakia.
Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University in Bratislava, Slovakia.
J Clin Neurosci. 2020 May;75:5-10. doi: 10.1016/j.jocn.2020.03.005. Epub 2020 Mar 23.
Data accumulated over the last two decades has demonstrated that hypothalamic inflammation plays an important role in the etiopathogenesis of the most prevalent diseases, such as cardiovascular diseases, metabolic syndrome, and even cancer. Recent findings indicate that hypothalamic inflammation is also associated with stress exposure and certain psychiatric diseases, such as depressive disorder. Mechanistic studies have shown that intense and/or chronic stress exposure is accompanied by the synthesis of inflammatory molecules in the hypothalamus, altered hypothalamic-pituitary-adrenal axis activity, and development of glucocorticoid resistance. Consequently, these factors might play a role in the etiopathogenesis of psychiatric disorders. We propose that hypothalamic inflammation represents an interconnection between somatic diseases and depressive disorder. These assumptions are discussed in this mini-review in the light of available data from studies focusing on hypothalamic inflammation.
过去二十年积累的数据表明，下丘脑炎症在最常见疾病（如心血管疾病、代谢综合征，甚至癌症）的发病机制中起着重要作用。最近的研究结果表明，下丘脑炎症也与应激暴露和某些精神疾病（如抑郁症）有关。机制研究表明，强烈和/或慢性应激暴露伴随着下丘脑炎症分子的合成、下丘脑-垂体-肾上腺轴活性的改变以及糖皮质激素抵抗的发展。因此，这些因素可能在精神疾病的发病机制中起作用。我们提出，下丘脑炎症代表了躯体疾病和抑郁症之间的联系。在本文中，我们根据关注下丘脑炎症的研究提供的数据，讨论了这些假设。
