Hereditary Tumours Research Group, 1089 Budapest, Hungary.
Department of Laboratory Medicine, Semmelweis University, 1089, Budapest, Hungary.
Molecules. 2020 Mar 25;25(7):1489. doi: 10.3390/molecules25071489.
Glucocorticoid hormones are vital; their accurate operation is a necessity at all ages and in all life situations. Glucocorticoids regulate diverse physiological processes and they use many signaling pathways to fulfill their effect. As the operation of these hormones affects many organs, the excess of glucocorticoids is actually detrimental to the whole human body. The endogenous glucocorticoid excess is a relatively rare condition, but a significant proportion of adult people uses glucocorticoid medication for the treatment of chronic illnesses, therefore they are exposed to the side effects of long-term glucocorticoid treatment. Our review summarizes the adverse effects of glucocorticoid excess affecting bones, adipose tissue, brain and skin, focusing on those effects which involve the Wnt/β-catenin pathway.
糖皮质激素至关重要；它们在各个年龄段和各种生活情况下的准确运作都是必需的。糖皮质激素调节多种生理过程，它们利用许多信号通路来发挥作用。由于这些激素的作用会影响许多器官，因此糖皮质激素的过量实际上对整个身体都是有害的。内源性糖皮质激素过多是一种相对罕见的情况，但相当一部分成年人使用糖皮质激素药物治疗慢性疾病，因此他们会接触到长期糖皮质激素治疗的副作用。我们的综述总结了糖皮质激素过多对骨骼、脂肪组织、大脑和皮肤的不良影响，重点介绍了涉及 Wnt/β-连环蛋白通路的那些影响。
