Yarema Nadiya, Kotsiuba Oksana, Krytskyy Taras, Marushchak Mariya, Krynytska Inna
I. Horbachevsky Ternopil National Medical University, Ukraine: Department of Internal Medicine No1.
I. Horbachevsky Ternopil National Medical University, Ukraine: Department of Terapeutics and Family Medicine.
Pol Merkur Lekarski. 2020 Feb 26;48(283):5-9.
As a long-term multisystem disorders, cardiovascular diseases can gravely affect on bone metabolism, prompting a severe bone loss and increasing predisposition to fractures and the development of osteoporosis.
The aim of the study was to analyze the peculiarities of bone mineral density (BMD), lipid spectrum, lipid peroxidation (LPO) and antioxidant system (AOS) activity in postmenopausal women with arterial hypertension (AH).
Using dual-energy X-ray absorptiometry, we measured BMD in 193 women aged 45-62 years with the Stage II of AH. Lipid profile, LPO and AOS status in blood plasma were determined.
In postmenopausal patients with hypertension, BMD and T-score values are significantly lower in comparison with the women of control group without hypertension (by 11.3% (p<0.05) and 14.4% (p<0.05) respectively). Independent predictors of osteoporosis progression in women with AHare the duration of disease, as well as menopause onset and the duration of postmenopausal period. In postmenopausal patients with AH there is a correlation dependence between the atherogenicity index and menopause duration (r=0.40, p<0.01), as well as the inverse correlation dependence between the atherogenicity index and the age of menopause onset (r =-0.27, p<0.01), which suggests that the earlier menopause in women with AH occurs, the faster the atherogenicity of plasma lipids progresses. Postmenopausal patients with AH showed higher indices of lipoperoxidation processes and simultaneous lower indices of antioxidant defence.
The bone mineral density in postmenopausal women with AH is significantly lower than in women of reproductive age. Independent predictors of osteoporosis progression in women with AH are the duration of disease, as well as menopause onset and the duration of postmenopausal period.
作为一种长期的多系统疾病，心血管疾病会严重影响骨代谢，导致严重的骨质流失，并增加骨折易感性和骨质疏松症的发生。
本研究旨在分析绝经后高血压（AH）女性的骨矿物质密度（BMD）、血脂谱、脂质过氧化（LPO）和抗氧化系统（AOS）活性的特点。
采用双能X线吸收法，我们测量了193名年龄在45 - 62岁、处于AH二期的女性的BMD。测定了血浆中的血脂谱、LPO和AOS状态。
绝经后高血压患者的BMD和T值显著低于无高血压的对照组女性（分别低11.3%（p<0.05）和14.4%（p<0.05））。AH女性骨质疏松进展的独立预测因素是疾病持续时间、绝经开始时间和绝经后时期的持续时间。在绝经后AH患者中，致动脉粥样硬化指数与绝经持续时间之间存在相关性（r = 0.40，p<0.01），并且致动脉粥样硬化指数与绝经开始年龄之间存在负相关（r = -0.27，p<0.01），这表明AH女性绝经越早，血浆脂质的动脉粥样硬化进展越快。绝经后AH患者显示出更高的脂质过氧化过程指标，同时抗氧化防御指标较低。
绝经后AH女性的骨矿物质密度显著低于育龄女性。AH女性骨质疏松进展的独立预测因素是疾病持续时间、绝经开始时间和绝经后时期的持续时间。
