Peculiarities of arterial hypertension in postmenopausal women with bone mineral density disorders and dyslipidemia.

UNLABELLED

As a long-term multisystem disorders, cardiovascular diseases can gravely affect on bone metabolism, prompting a severe bone loss and increasing predisposition to fractures and the development of osteoporosis.

AIM

The aim of the study was to analyze the peculiarities of bone mineral density (BMD), lipid spectrum, lipid peroxidation (LPO) and antioxidant system (AOS) activity in postmenopausal women with arterial hypertension (AH).

MATERIALS AND METHODS

Using dual-energy X-ray absorptiometry, we measured BMD in 193 women aged 45-62 years with the Stage II of AH. Lipid profile, LPO and AOS status in blood plasma were determined.

RESULTS

In postmenopausal patients with hypertension, BMD and T-score values are significantly lower in comparison with the women of control group without hypertension (by 11.3% (p<0.05) and 14.4% (p<0.05) respectively). Independent predictors of osteoporosis progression in women with AHare the duration of disease, as well as menopause onset and the duration of postmenopausal period. In postmenopausal patients with AH there is a correlation dependence between the atherogenicity index and menopause duration (r=0.40, p<0.01), as well as the inverse correlation dependence between the atherogenicity index and the age of menopause onset (r =-0.27, p<0.01), which suggests that the earlier menopause in women with AH occurs, the faster the atherogenicity of plasma lipids progresses. Postmenopausal patients with AH showed higher indices of lipoperoxidation processes and simultaneous lower indices of antioxidant defence.

CONCLUSIONS

The bone mineral density in postmenopausal women with AH is significantly lower than in women of reproductive age. Independent predictors of osteoporosis progression in women with AH are the duration of disease, as well as menopause onset and the duration of postmenopausal period.