Department of Urology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.
Biomed Res Int. 2020 Mar 6;2020:8051210. doi: 10.1155/2020/8051210. eCollection 2020.
The aim of this study was to investigate the prognostic significance of the preoperative neutrophil-to-lymphocyte ratio (NLR) in small renal cell carcinoma (sRCC, ≤4 cm).
This study was approved by the review board (NO.XYFY2019-KL032-01). Between 2007 and 2016, a total of 384 consecutive patients who underwent curative surgery for sRCC at our institution were evaluated. Patients were divided into high NLR and low NLR groups by plotting the NLR receiver operating characteristic curve. The Kaplan-Meier method was utilized to graphically display survivor functions. Univariate and multivariate Cox proportional hazards regression analysis addressed time to overall survival (OS) and cancer-specific survival (CSS).
Of the 384 patients, 264 (68.8%) were males and 120 (31.2%) were females. Median follow-up time after surgical resection was 54 months. One hundred and eighty-seven (48.7%) patients had a high NLR (≥1.97), and the remaining 197 (51.3%) had a low NLR (<1.97). Patients with high NLR were more likely to be aged compared with patients with low NLR (=0.028). High NLR was associated with decreased OS and CSS compared with low NLR (=0.028). High NLR was associated with decreased OS and CSS compared with low NLR (=0.028). High NLR was associated with decreased OS and CSS compared with low NLR (=0.028). High NLR was associated with decreased OS and CSS compared with low NLR (.
Elevated preoperative NLR is an independent adverse prognostic factor for OS after surgery with curative intent for sRCC.
本研究旨在探讨术前中性粒细胞与淋巴细胞比值（NLR）对小肾细胞癌（sRCC，≤4cm）的预后意义。
本研究经审查委员会批准（编号：XYFY2019-KL032-01）。2007 年至 2016 年间，对在我院接受根治性手术治疗的 384 例 sRCC 患者进行了评估。通过 NLR 受试者工作特征曲线绘制将患者分为高 NLR 组和低 NLR 组。采用 Kaplan-Meier 法绘制生存函数图。单因素和多因素 Cox 比例风险回归分析用于评估总生存（OS）和癌症特异性生存（CSS）的时间。
384 例患者中，男性 264 例（68.8%），女性 120 例（31.2%）。术后切除后中位随访时间为 54 个月。187 例（48.7%）患者 NLR 较高（≥1.97），其余 197 例（51.3%）患者 NLR 较低（<1.97）。与 NLR 较低的患者相比，NLR 较高的患者年龄更大（=0.028）。与 NLR 较低的患者相比，NLR 较高的患者 OS 和 CSS 较低（=0.028）。与 NLR 较低的患者相比，NLR 较高的患者 OS 和 CSS 较低（=0.028）。与 NLR 较低的患者相比，NLR 较高的患者 OS 和 CSS 较低（=0.028）。
术前 NLR 升高是 sRCC 根治性手术后 OS 的独立不良预后因素。
