Ohno Yoshio
Department of Urology, Tokyo Medical University, Tokyo, Japan.
Int J Urol. 2019 Jan;26(1):31-47. doi: 10.1111/iju.13801. Epub 2018 Sep 25.
The systemic inflammatory response is associated with survival in patients with a variety of cancers. This inflammatory response is measured in the peripheral blood, and can be monitored using two categories of indices: concentration of specific serum proteins (albumin, C-reactive protein) and differential blood cell count (neutrophils, lymphocytes and platelets). Furthermore, combinations of these indices, such as the Glasgow Prognostic Score, which consists of the serum C-reactive protein and albumin level; the neutrophil-to-lymphocyte ratio; the platelet-to-lymphocyte ratio; and the prognostic nutritional index, which is based on peripheral blood lymphocyte count and serum albumin level, have also been evaluated and compared in cancer research. To date, there are hundreds of studies that have shown the prognostic value of systemic inflammatory response markers in patients with urological cancer. Most studies have evaluated the prognostic and predictive role of the pretreatment value of the markers, although some have focused on the role of the post-treatment value at specific points during the clinical course. The advantages of systemic inflammatory response markers are that they are easily measurable and inexpensive in the clinical setting. However, it is important to consider how clinicians use these markers in clinical practice. The present review provides a concise overview regarding systemic inflammatory markers in urological cancers, specifically C-reactive protein, Glasgow Prognostic Score/modified Glasgow Prognostic Score, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and prognostic nutritional index.
全身炎症反应与多种癌症患者的生存情况相关。这种炎症反应可在外周血中检测到，并可使用两类指标进行监测：特定血清蛋白（白蛋白、C反应蛋白）的浓度以及血细胞分类计数（中性粒细胞、淋巴细胞和血小板）。此外，这些指标的组合，如由血清C反应蛋白和白蛋白水平组成的格拉斯哥预后评分；中性粒细胞与淋巴细胞比值；血小板与淋巴细胞比值；以及基于外周血淋巴细胞计数和血清白蛋白水平的预后营养指数，也在癌症研究中得到了评估和比较。迄今为止，已有数百项研究表明全身炎症反应标志物在泌尿生殖系统癌症患者中的预后价值。大多数研究评估了这些标志物治疗前值的预后和预测作用，不过也有一些研究聚焦于临床过程中特定时间点的治疗后值的作用。全身炎症反应标志物的优点在于它们在临床环境中易于测量且成本低廉。然而，重要的是要考虑临床医生在临床实践中如何使用这些标志物。本综述简要概述了泌尿生殖系统癌症中的全身炎症标志物，特别是C反应蛋白、格拉斯哥预后评分/改良格拉斯哥预后评分、中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值以及预后营养指数。
