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冷大气压等离子体放电装置具有抗菌作用。

A Cold Atmospheric Pressure Plasma Discharge Device Exerts Antimicrobial Effects.

作者信息

Cornell Kenneth A, Benfield Kate, Berntsen Tiffany, Clingerman Jenna, Croteau Adam, Goering Spencer, Moyer Daniel, Provost Mariah, White Amanda, Plumlee Don, Oxford Julia T, Browning Jim

机构信息

Department of Chemistry and Biochemistry, Boise State University, Boise, ID USA.

Department of Mechanical and Biomedical Engineering, Boise State University, Boise, ID USA.

出版信息

Int J Latest Trends Eng Technol. 2020 Jan;15(3):036-41.

PMID:32219149
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7098701/
Abstract

A cold atmospheric pressure plasma device was developed using two parallel plates of Low Temperature Co-fired Ceramic with embedded electrodes. The 2.4 cm wide by 1 mm deep plasma discharge operates at 20 kHz with a 2-5 kV AC drive signal across a 0.25 mm gap. Mixed Argon/oxygen plasmas were directed between the plates to flow toward a bacterial biofilm sample for treatment. Results showed that at 4-5 kV the plasma etched away a bacterial biofilm on glass in 10 minutes. In addition, we showed that short plasma treatments rapidly killed biofilm resident bacteria with ED values of <15 s.

摘要

一种冷大气压等离子体装置是利用两块嵌入电极的低温共烧陶瓷平行板研制而成。宽2.4厘米、深1毫米的等离子体放电以20千赫兹运行,在0.25毫米的间隙上施加2 - 5千伏的交流驱动信号。混合氩/氧等离子体在极板之间定向流动,流向细菌生物膜样本进行处理。结果表明,在4 - 5千伏时,等离子体在10分钟内蚀刻掉了玻璃上的细菌生物膜。此外,我们还表明,短时间的等离子体处理能迅速杀死生物膜中的细菌,等效致死剂量值小于15秒。

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引用本文的文献

1
Cold Atmospheric Pressure Plasma Device Exhibits Etching Effects on Bacterial Biofilms.冷大气压等离子体装置对细菌生物膜具有蚀刻作用。
IEEE Trans Radiat Plasma Med Sci. 2022 May;6(5):619-625. doi: 10.1109/trpms.2021.3133183. Epub 2021 Dec 7.
2
Fabrication and Performance of a Multi-Discharge Cold Atmospheric Pressure Plasma Array.一种多放电冷大气压等离子体阵列的制备与性能
IEEE Trans Plasma Sci IEEE Nucl Plasma Sci Soc. 2021 Apr;49(4):1388-1395. doi: 10.1109/TPS.2021.3064993. Epub 2021 Mar 23.

本文引用的文献

1
Biofilms in Food Processing Environments: Challenges and Opportunities.食品加工环境中的生物膜:挑战与机遇。
Annu Rev Food Sci Technol. 2019 Mar 25;10:173-195. doi: 10.1146/annurev-food-032818-121805. Epub 2019 Jan 17.
2
The Potential of Cold Plasma for Safe and Sustainable Food Production.冷等离子体在安全可持续食品生产方面的潜力。
Trends Biotechnol. 2018 Jun;36(6):615-626. doi: 10.1016/j.tibtech.2017.11.001. Epub 2018 Jan 9.
3
An Economic Evaluation of the Impact, Cost, and Medicare Policy Implications of Chronic Nonhealing Wounds.慢性难愈合伤口的影响、成本及医疗保险政策影响的经济评估
Value Health. 2018 Jan;21(1):27-32. doi: 10.1016/j.jval.2017.07.007. Epub 2017 Sep 19.
4
Microbial Biofilms and Chronic Wounds.微生物生物膜与慢性伤口
Microorganisms. 2017 Mar 7;5(1):9. doi: 10.3390/microorganisms5010009.
5
Cold plasma inactivation of chronic wound bacteria.冷等离子体对慢性伤口细菌的灭活作用
Arch Biochem Biophys. 2016 Sep 1;605:76-85. doi: 10.1016/j.abb.2016.03.033. Epub 2016 Apr 1.
6
Health economic burden that wounds impose on the National Health Service in the UK.伤口给英国国民医疗服务体系带来的健康经济负担。
BMJ Open. 2015 Dec 7;5(12):e009283. doi: 10.1136/bmjopen-2015-009283.
7
Cold Plasma Inactivation of Bacterial Biofilms and Reduction of Quorum Sensing Regulated Virulence Factors.冷等离子体对细菌生物膜的灭活作用及群体感应调控的毒力因子的减少
PLoS One. 2015 Sep 21;10(9):e0138209. doi: 10.1371/journal.pone.0138209. eCollection 2015.
8
Biofilms and Wounds: An Overview of the Evidence.生物膜与伤口:证据概述
Adv Wound Care (New Rochelle). 2015 Jul 1;4(7):373-381. doi: 10.1089/wound.2014.0557.
9
Pseudomonas aeruginosa Biofilm Response and Resistance to Cold Atmospheric Pressure Plasma Is Linked to the Redox-Active Molecule Phenazine.铜绿假单胞菌生物膜对冷大气压等离子体的反应及抗性与氧化还原活性分子吩嗪有关。
PLoS One. 2015 Jun 26;10(6):e0130373. doi: 10.1371/journal.pone.0130373. eCollection 2015.
10
Photons and particles emitted from cold atmospheric-pressure plasma inactivate bacteria and biomolecules independently and synergistically.冷等离体大气压射流中发射的光子和粒子可独立和协同地使细菌和生物分子失活。
J R Soc Interface. 2013 Sep 25;10(89):20130591. doi: 10.1098/rsif.2013.0591. Print 2013 Dec 6.