Barraviera B, Mendes R P, Pereira P C, Machado J M, Curi P R, Meira D A
Department of Infectious and Parasitologic Diseases, São Paulo, Brazil.
Mycopathologia. 1988 Nov;104(2):87-91. doi: 10.1007/BF00436932.
Hemoglobin rates, hematocrit and glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase activities were measured in 38 patients with paracoccidioidomycosis treated with ketoconazole or sulfadoxin, and in 13 normal individuals. Ketoconazole-treated patients showed reduced G6PD and glutathione reductase activities. One of these patients was found to be G6PD-deficient and suffered a hemolytic episode during treatment, which, however, did not require interruption of therapy. The authors suggest that patients showing an erythrocyte enzyme defect should be monitored hematologically during treatment with ketoconazole. They also suggest that ketoconazole is an oxidant drug in addition to being a possible inhibitor of antioxidant erythrocyte enzymes.
对38例接受酮康唑或磺胺多辛治疗的副球孢子菌病患者以及13名正常个体测定了血红蛋白率、血细胞比容、葡萄糖-6-磷酸脱氢酶（G6PD）和谷胱甘肽还原酶活性。接受酮康唑治疗的患者G6PD和谷胱甘肽还原酶活性降低。其中1例患者被发现G6PD缺乏，在治疗期间发生溶血发作，但无需中断治疗。作者建议，酮康唑治疗期间，红细胞酶缺陷患者应进行血液学监测。他们还认为，酮康唑除了可能抑制红细胞抗氧化酶外，还是一种氧化药物。
