Krungkrai S R, Yuthavong Y
Department of Biochemistry, Rajavithi Hospital, Bangkok, Thailand.
Trans R Soc Trop Med Hyg. 1987;81(5):710-4. doi: 10.1016/0035-9203(87)90003-4.
The antimalarial activity of qinghaosu (artemisinine) against Plasmodium falciparum in culture was enhanced by increased oxygen tension. Artesunate, a qinghaosu derivative, showed synergistic effects with miconazole, and with doxorubicin, both of which have been suggested to exert their chemotherapeutic effect through increasing the oxidant stress. In contrast, catalase, dithiothreitol and alpha-tocopherol reduced the effectiveness of qinghaosu in vitro. These results suggest that the action of qinghaosu and artesunate might involve increase in oxidant stress on the infected red cells.
青蒿素（青蒿琥酯）在体外培养中对恶性疟原虫的抗疟活性会因氧张力增加而增强。青蒿琥酯是青蒿素的衍生物，与咪康唑和阿霉素均呈现协同效应，这两种药物都被认为是通过增加氧化应激来发挥其化疗作用的。相比之下，过氧化氢酶、二硫苏糖醇和α-生育酚在体外会降低青蒿素的有效性。这些结果表明，青蒿素和青蒿琥酯的作用可能涉及增加被感染红细胞的氧化应激。
