Novel Genetic Variant of a Class B G Protein-Coupled Receptor Reveals a Role for Adrenomedullin in Human Fertility.
作者信息
Hay Debbie L
机构信息
School of Biological Sciences and Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, 1010, New Zealand.
出版信息
ACS Pharmacol Transl Sci. 2018 Sep 21;1(2):138-139. doi: 10.1021/acsptsci.8b00038. eCollection 2018 Nov 9.
Abstract
摘要
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本文引用的文献
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Cryo-EM structure of the active, G-protein complexed, human CGRP receptor.活性态、与 G 蛋白复合物结合的人降钙素基因相关肽受体的冷冻电镜结构。
Nature. 2018 Sep;561(7724):492-497. doi: 10.1038/s41586-018-0535-y. Epub 2018 Sep 12.
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h mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.h 突变导致常染色体隐性遗传非免疫性胎儿水肿伴淋巴管发育不良。
J Exp Med. 2018 Sep 3;215(9):2339-2353. doi: 10.1084/jem.20180528. Epub 2018 Aug 16.
3
Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis.内异症患者在位内膜和血浆中肾上腺髓质素水平升高。
Fertil Steril. 2018 Jun;109(6):1072-1078. doi: 10.1016/j.fertnstert.2018.02.004. Epub 2018 Jun 2.
4
Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis.肾上腺髓质素和肾上腺髓质素靶向治疗作为脓毒症相关的治疗策略。
Front Immunol. 2018 Feb 19;9:292. doi: 10.3389/fimmu.2018.00292. eCollection 2018.
5
Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25.降钙素/CGRP 肽家族药理学的最新进展：IUPHAR 评论 25。
Br J Pharmacol. 2018 Jan;175(1):3-17. doi: 10.1111/bph.14075. Epub 2017 Nov 28.
6
Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor.G蛋白偶联受体依赖受体活性修饰蛋白的选择性肽识别的结构基础
Mol Cell. 2015 Jun 18;58(6):1040-52. doi: 10.1016/j.molcel.2015.04.018. Epub 2015 May 14.
7
Understanding RAMPs through genetically engineered mouse models.通过基因工程小鼠模型了解 RAMPs。
Adv Exp Med Biol. 2012;744:49-60. doi: 10.1007/978-1-4614-2364-5_5.
8
Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice.研究资源：受体活性修饰蛋白2（RAMP2）单倍剂量不足会导致小鼠生育能力下降、高催乳素血症、骨骼异常和内分泌功能障碍。
Mol Endocrinol. 2011 Jul;25(7):1244-53. doi: 10.1210/me.2010-0400. Epub 2011 May 12.
9
Adrenomedullin signaling is necessary for murine lymphatic vascular development.肾上腺髓质素信号传导对于小鼠淋巴管发育是必需的。
J Clin Invest. 2008 Jan;118(1):40-50. doi: 10.1172/JCI33302.
10
The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.G蛋白偶联受体（GPCR）调节蛋白RAMP2对血管生成和血管完整性至关重要。
J Clin Invest. 2008 Jan;118(1):29-39. doi: 10.1172/JCI33022.
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