Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, viale Annunziata, I-98168 Messina, Italy.
Department of Health Sciences, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
Food Funct. 2020 Apr 30;11(4):3271-3279. doi: 10.1039/d0fo00089b.
Several studies published in the last decade suggest that the beneficial role of extra-virgin olive oil (EVOO) in human health is mostly attributable to the main secoiridoid derivatives (oleuropein, oleocanthal, and oleacein). Anti-cancer properties have also been demonstrated for certain compounds present in small quantities in EVOO, including oleuropein and hydroxytyrosol, which have been extensively studied, while minor attention has been given to the most abundant secoiridoid oleacein. The aim of our research was to study the molecular mechanisms underlying the anti-proliferative and anti-metastatic capacity of oleacein in the SH-SY5Y human neuroblastoma cell line. Our results demonstrate that oleacein is able to reduce the proliferation of the SH-SY5Y cells by blocking the cell cycle in the S phase and inducing apoptotic cell death through the increase in both Bax and p53 as well as a reduction in the Bcl-2 expression and STAT3 phosphorylation. Moreover, oleacein caused reduction in the SH-SY5Y cell adhesion and migration. Overall, these findings indicate that oleacein exerts anti-cancer effects against neuroblastoma cells, suggesting a promising role as a candidate against this type of cancer.
过去十年发表的几项研究表明，特级初榨橄榄油（EVOO）对人体健康的有益作用主要归因于主要的次级愈创木脂素衍生物（橄榄苦苷、橄榄苦素和橄榄烯）。EVOO 中存在的某些含量较少的化合物也具有抗癌特性，包括橄榄苦苷和羟基酪醇，它们已经得到了广泛的研究，而对最丰富的次级愈创木脂素橄榄烯则关注较少。我们的研究旨在研究橄榄烯在人神经母细胞瘤 SH-SY5Y 细胞系中的抗增殖和抗转移能力的分子机制。我们的研究结果表明，橄榄烯能够通过阻断 S 期细胞周期并通过增加 Bax 和 p53 以及降低 Bcl-2 表达和 STAT3 磷酸化来诱导细胞凋亡，从而减少 SH-SY5Y 细胞的增殖。此外，橄榄烯还导致 SH-SY5Y 细胞的黏附和迁移减少。总的来说，这些发现表明橄榄烯对神经母细胞瘤细胞具有抗癌作用，表明其作为治疗这种癌症的候选药物具有广阔的前景。
