镰状细胞病患者的肾脏中存在含铁血黄素 A1M。
Heme A1M'ed at the kidney in sickle cell disease.
机构信息
University of Illinois at Chicago.
出版信息
Blood. 2020 Mar 26;135(13):979-981. doi: 10.1182/blood.2020005134.
Abstract
In this issue of , Ofori-Acquah et al investigate hemolysis, hemopexin deficiency, and kidney function in sickle cell disease (SCD) and report that (1) acute elevations in heme lead to kidney damage in hemopexin-deficient states, and (2) a compensatory rise in α-1 microglobulin (A1M) relative to hemopexin concentration is associated with acute kidney injury.
摘要
本期《 》中，Ofori-Acquah 等人研究了镰状细胞病（SCD）中的溶血、血色素结合蛋白缺乏和肾功能，并报告（1）游离血红素的急性升高会导致血色素结合蛋白缺乏状态下的肾脏损伤，以及（2）α-1 微球蛋白（A1M）与血色素结合蛋白浓度的相对代偿性升高与急性肾损伤相关。
相似文献
1
Heme A1M'ed at the kidney in sickle cell disease.镰状细胞病患者的肾脏中存在含铁血黄素 A1M。
Blood. 2020 Mar 26;135(13):979-981. doi: 10.1182/blood.2020005134.
2
Hemopexin deficiency promotes acute kidney injury in sickle cell disease.贫血抑制素缺乏促进镰状细胞病急性肾损伤。
Blood. 2020 Mar 26;135(13):1044-1048. doi: 10.1182/blood.2019002653.
3
Differences in heme and hemopexin content in lipoproteins from patients with sickle cell disease.镰状细胞病患者脂蛋白中血红素和血红素结合蛋白含量的差异。
J Clin Lipidol. 2018 Nov-Dec;12(6):1532-1538. doi: 10.1016/j.jacl.2018.08.002. Epub 2018 Aug 14.
4
Critical Role of Hemopexin Mediated Cytoprotection in the Pathophysiology of Sickle Cell Disease.血红素结合蛋白介导的细胞保护在镰状细胞病病理生理学中的关键作用。
Int J Mol Sci. 2021 Jun 15;22(12):6408. doi: 10.3390/ijms22126408.
5
Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.触珠蛋白和血红素结合蛋白抑制小鼠镰状细胞病中的血管闭塞和炎症：血红素加氧酶-1 诱导的作用。
PLoS One. 2018 Apr 25;13(4):e0196455. doi: 10.1371/journal.pone.0196455. eCollection 2018.
6
Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles.血管内溶血通过游离血红素和载血红素的微囊泡激活补体。
JCI Insight. 2018 Jun 21;3(12). doi: 10.1172/jci.insight.96910.
7
Immunoelectrophoretic studies of the beta1-haem-binding globulin (haemopexin) in hereditary haemolytic disorders.遗传性溶血性疾病中β1-血红素结合球蛋白（血红素结合蛋白）的免疫电泳研究。
Nature. 1963 Feb 9;197:602-3. doi: 10.1038/197602a0.
8
Hemopexin metabolism in sickle-cell disease, porphyrias and control subjects--effects of heme injection.镰状细胞病、卟啉症及对照受试者中的血红素结合蛋白代谢——血红素注射的影响
N Engl J Med. 1974 Apr 11;290(15):822-6. doi: 10.1056/NEJM197404112901503.
9
Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases.血红素结合蛋白治疗通过预防溶血性疾病小鼠模型中的血红素诱导的内皮毒性来改善心血管功能。
Circulation. 2013 Mar 26;127(12):1317-29. doi: 10.1161/CIRCULATIONAHA.112.130179. Epub 2013 Feb 27.
10
Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria.系统性细胞外血红素和血红素结合蛋白的改变与乌干达重症疟疾儿童的不良临床结局相关。
J Infect Dis. 2016 Oct 15;214(8):1268-75. doi: 10.1093/infdis/jiw357. Epub 2016 Aug 11.
引用本文的文献
1
Therapeutics for sickle cell disease intravascular hemolysis.镰状细胞病血管内溶血的治疗方法。
Front Physiol. 2024 Sep 13;15:1474569. doi: 10.3389/fphys.2024.1474569. eCollection 2024.
2
Hemolysis scavenger proteins and renal function marker in children with sickle cell disease at steady state: A cross-sectional study.稳态下镰状细胞病患儿的溶血清除蛋白与肾功能标志物：一项横断面研究
Health Sci Rep. 2023 Mar 30;6(4):e1177. doi: 10.1002/hsr2.1177. eCollection 2023 Apr.
3
The Role of α-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis-Therapeutic Opportunities in Hemolytic Conditions.α-微球蛋白（A1M）在红细胞生成和红细胞内稳态中的作用-溶血性疾病的治疗机会。
Int J Mol Sci. 2020 Sep 30;21(19):7234. doi: 10.3390/ijms21197234.
本文引用的文献
1
Hemopexin deficiency promotes acute kidney injury in sickle cell disease.贫血抑制素缺乏促进镰状细胞病急性肾损伤。
Blood. 2020 Mar 26;135(13):1044-1048. doi: 10.1182/blood.2019002653.
2
Mechanisms of haemolysis-induced kidney injury.溶血导致肾损伤的机制。
Nat Rev Nephrol. 2019 Nov;15(11):671-692. doi: 10.1038/s41581-019-0181-0. Epub 2019 Aug 27.
3
and acute kidney injury in sickle cell anemia.以及镰状细胞贫血中的急性肾损伤。
Blood. 2018 Oct 11;132(15):1621-1625. doi: 10.1182/blood-2018-05-853929. Epub 2018 Aug 23.
4
Acute kidney injury during a pediatric sickle cell vaso-occlusive pain crisis.小儿镰状细胞血管阻塞性疼痛危象期间的急性肾损伤
Pediatr Nephrol. 2017 Aug;32(8):1451-1456. doi: 10.1007/s00467-017-3623-6. Epub 2017 Feb 25.
5
Acute kidney injury and chronic kidney disease as interconnected syndromes.急性肾损伤与慢性肾脏病：相互关联的综合征
N Engl J Med. 2014 Jul 3;371(1):58-66. doi: 10.1056/NEJMra1214243.
6
Albuminuria correlates with hemolysis and NAG and KIM-1 in patients with sickle cell anemia.镰状细胞贫血患者的蛋白尿与溶血、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）和肾损伤分子-1（KIM-1）相关。
Pediatr Nephrol. 2014 Oct;29(10):1997-2003. doi: 10.1007/s00467-014-2821-8. Epub 2014 Jun 3.
7
Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload.血红素结合蛋白可预防血红素过载小鼠模型中的内皮损伤和肝脏充血。
Am J Pathol. 2008 Jul;173(1):289-99. doi: 10.2353/ajpath.2008.071130. Epub 2008 Jun 13.
8
Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice.血红素结合蛋白缺陷小鼠急性溶血后恢复缺陷及严重肾损伤。
Blood. 1999 Dec 1;94(11):3906-14.
9
10
Plasma hemoglobin and hemoglobin fractions in sickle cell crisis.
Am J Clin Pathol. 1971 Aug;56(2):137-47. doi: 10.1093/ajcp/56.2.137.
Zotero 插件