Losiowski Z, Prokopczyk J, Zimak J, Bielicka J
Kliniki Neurologii Dzieci i Młodziezy, Instytutu Matki i Dziecka w Warszawie.
Neurol Neurochir Pol. 1988 May-Jun;22(3):195-200.
After determination of carbamazepine level in plasma by means of gas chromatography 23 profiles of 24-hour concentrations were plotted in children aged from 20 months to 15 years treated for epilepsy. In 12 of them monotherapy was given (Amizepin-Polfa in a mean daily dose of 18.7 mg/kg) while polytherapy was given to 11 children (mean daily dose was 21.1 mg/kg). Considerable fluctuations of the level of the drug were found in the plasma over 24 hours in various children, and individual differences after the administration of carbamazepine alone or with other drugs. The 24-hour fluctuations of total carbamazepine in the plasma and individual differences are due, probably, to pharmacokinetic factors due to physiological differences between patients and were correlated more to the age of the child than to the administered dose.
通过气相色谱法测定血浆中卡马西平的浓度后，绘制了20个月至15岁癫痫患儿24小时浓度的23条曲线。其中12名患儿接受单一疗法（阿米替林 - 波法，平均日剂量为18.7mg/kg），11名患儿接受联合疗法（平均日剂量为21.1mg/kg）。在不同患儿中发现，血浆中药物浓度在24小时内有相当大的波动，单独服用卡马西平或与其他药物合用时存在个体差异。血浆中总卡马西平的24小时波动和个体差异可能归因于患者生理差异导致的药代动力学因素，并且与患儿年龄的相关性大于与给药剂量的相关性。
