Czochańska J, Losiowski Z, Prokopczyk J, Zimak J
Neurol Neurochir Pol. 1987 Jan-Feb;21(1):6-10.
Evaluating in 62 children aged from 4 months to 14 years (mean age 3 years 7 months) the correlation between the carbamazepine dosage (carbamazepine was given as the only drug in 21 cases, and as one of several drugs in 41) the authors failed to find a simple correlation. Nevertheless, most children receiving the "proper" doses had therapeutic plasma carbamazepine levels. Moreover, it was found that carbamazepine dose increase over 25 mg/kg daily caused on further rise of its plasma level.
在对62名年龄从4个月至14岁(平均年龄3岁7个月)的儿童进行评估时,研究了卡马西平剂量(21例中卡马西平作为唯一药物使用,41例中作为几种药物之一使用)之间的相关性,作者未能发现简单的相关性。然而,大多数接受“合适”剂量的儿童血浆卡马西平水平处于治疗范围。此外,还发现卡马西平每日剂量增加超过25mg/kg时,其血浆水平并未进一步升高。