Department of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria.
Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Trop Med Int Health. 2020 Jun;25(6):660-665. doi: 10.1111/tmi.13395. Epub 2020 Apr 16.
Tropical pyomyositis (TP) is a life-threatening bacterial infection of the skeletal muscle that occurs particularly among children, young adults and those with immunocompromised conditions. The appropriate diagnosis and treatment are often delayed due to its non-specific signs, leading to fatal consequences. Staphylococcus aureus, especially methicillin-susceptible S. aureus, is responsible for most TP cases. However, other bacteria (i.e. streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Candida spp., Mycobacterium spp.) have been reported. This narrative review provides an update on the epidemiology and clinical course of TP. A special focus is laid on the role of toxins (i.e. Panton-Valentine Leucocidin and α-toxin) in the pathogenesis of TP and their implication for the clinical management of infection.
热带肌炎（TP）是一种危及生命的骨骼肌肉细菌感染，尤其常见于儿童、青年和免疫功能低下者。由于其非特异性体征，诊断和治疗往往会被延误，导致致命后果。金黄色葡萄球菌，特别是甲氧西林敏感的金黄色葡萄球菌，是大多数 TP 病例的致病菌。然而，也有其他细菌（即链球菌、铜绿假单胞菌、大肠杆菌、克雷伯菌属、念珠菌属、分枝杆菌属）被报道过。本综述介绍了 TP 的流行病学和临床病程的最新情况。特别关注的是毒素（即 Panton-Valentine 白细胞毒素和 α-毒素）在 TP 发病机制中的作用及其对感染临床管理的影响。
