治愈 HIV：寻求靶向和清除持续性感染。
Curing HIV: Seeking to Target and Clear Persistent Infection.
机构信息
UNC HIV Cure Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Epidemiology, University of North Carolina at Chapel Hill School of Public Health, Chapel Hill, NC 27599, USA.
UNC HIV Cure Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA; Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
出版信息
Cell. 2020 Apr 2;181(1):189-206. doi: 10.1016/j.cell.2020.03.005. Epub 2020 Mar 26.
Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of antiretroviral therapy (ART). To remove the stigma and burden of chronic infection, approaches to eradicate or cure HIV infection are desired. Attempts to augment ART with therapies that reverse viral latency, paired with immunotherapies to clear infection, have advanced into the clinic, but the field is still in its infancy. We review foundational studies and highlight new insights in HIV cure research. Together with advances in ART delivery and HIV prevention strategies, future therapies that clear HIV infection may relieve society of the affliction of the HIV pandemic.
人类免疫缺陷病毒 1 型（HIV-1）感染尽管经过多年的抗逆转录病毒治疗（ART）仍持续存在。为了消除慢性感染的耻辱和负担，人们希望寻求消除或治愈 HIV 感染的方法。尝试用逆转病毒潜伏期的疗法来增强 ART，并结合清除感染的免疫疗法，已经进入临床阶段，但该领域仍处于起步阶段。我们回顾了基础研究，并强调了 HIV 治愈研究的新见解。随着 ART 输送和 HIV 预防策略的进步，清除 HIV 感染的未来疗法可能会使社会摆脱 HIV 大流行的困扰。
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