Department of Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran; Students' Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran; Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Clin Nutr ESPEN. 2020 Apr;36:111-115. doi: 10.1016/j.clnesp.2020.01.007. Epub 2020 Jan 31.
In human, advanced glycation end products (AGEs) can endogenously formed or exogenously ingested from foods and tobacco. Dietary quality is an important factor to prevent many disorders. This study sought to determine any association between AGEs and diet quality.
The participants were 90 healthy adults, aged higher than 20 years. Dietary intake of individuals was collected using two 24-h dietary recalls and quality of diets were determined by dietary quality index-International (DQI-I). Serum levels of pentosidine and carboxymethyl-lysine (CML) were examined by ELISA.
Total DQI-I score was 62.3 ± 1.3. Variety, adequacy, moderation, and the overall balance of diet scores in the study participants were 16.5 ± 0.4, 25.8 ± 0.5, 17.7 ± 0.9, and 2.4 ± 0.3, respectively. Participants with higher age (>40 years), higher education level, moderate calorie intake and married had significantly greater DQI-I score. Diet quality was positively associated with participants' education level (r = 0.28, p = 0.008). DQI-I score negatively correlated with serum levels of CML and pentosidine (r = -0.42, P < 0.001 and r = -0.35, P < 0.001, respectively).
Dietary modification may be beneficial for controlling AGE accumulation in the body and subsequently in reduction of chronic diseases risk.
在人类中，晚期糖基化终产物（AGEs）可以内源性形成或从食物和烟草中外源性摄入。饮食质量是预防多种疾病的重要因素。本研究旨在确定 AGEs 与饮食质量之间的任何关联。
参与者为 90 名年龄在 20 岁以上的健康成年人。个体的饮食摄入量通过两次 24 小时饮食回忆收集，饮食质量通过饮食质量指数-国际（DQI-I）确定。血清戊糖素和羧甲基赖氨酸（CML）水平通过 ELISA 检测。
总 DQI-I 得分为 62.3±1.3。研究参与者的多样性、充足性、适度性和饮食整体平衡得分分别为 16.5±0.4、25.8±0.5、17.7±0.9 和 2.4±0.3。年龄较大（>40 岁）、教育程度较高、热量摄入适中且已婚的参与者 DQI-I 得分显著较高。饮食质量与参与者的教育程度呈正相关（r=0.28，p=0.008）。DQI-I 得分与血清 CML 和戊糖素水平呈负相关（r=-0.42，P<0.001 和 r=-0.35，P<0.001）。
饮食调整可能有益于控制体内 AGE 积累，从而降低慢性病风险。
