Romano J H, Hitchings R A, Pooinasawmy D
Glaucoma Unit, Moorfields Eye Hospital, London, England.
Ophthalmic Surg. 1988 Nov;19(11):814-6. doi: 10.3928/0090-4481-19881101-12.
One half of 20 patients (40 eyes) with ocular hypertension and occludable angles, some with peripheral anterior synechiae, were randomly assigned for treatment by Nd:YAG laser iridotomy. Pre-randomization patients required pilocarpine to maintain normal intraocular tension. Following laser treatment, all eyes were followed a minimum of 12 months (mean of 24). In the nonlaser-treated group, pilocarpine alone controlled intraocular pressure. In the laser treated group, eyes without peripheral anterior synechiae required fewer medications to maintain normal pressures while eyes with peripheral anterior synechiae required more. Although relief of pupillary block by laser iridotomy can facilitate management of this group of patients, preexisting peripheral anterior synechiae may be associated with greater therapeutic requirements following laser treatment.
20例患有高眼压症且房角可关闭（部分伴有周边前粘连）的患者（40只眼），其中一半被随机分配接受Nd:YAG激光虹膜切开术治疗。随机分组前，患者需要使用毛果芸香碱来维持正常眼压。激光治疗后，所有眼睛至少随访12个月（平均24个月）。在未接受激光治疗的组中，单独使用毛果芸香碱可控制眼压。在接受激光治疗的组中，没有周边前粘连的眼睛维持正常眼压所需的药物较少，而有周边前粘连的眼睛所需药物较多。虽然激光虹膜切开术解除瞳孔阻滞有助于管理这组患者，但术前存在的周边前粘连可能与激光治疗后更高的治疗需求相关。
